• 27 September 1879: Established as Apostolic Prefecture of Gold Coast from the Apostolic Vicariate of Two Guineas in Gabon
• 25 May 1901: Promoted as Apostolic Vicariate of Gold Coast^[1]
• 18 April 1950: Promoted as Metropolitan Archdiocese of Cape Coast^[2]

The Archdiocese has been^[when?] generous in supplying priests for underserved areas of the United States; for example, in the Roman Catholic Diocese of Victoria in Texas, 16 of the 64 priests are from Ghana. Many have been incardinated into the archdiocese, have become U.S. citizens, and serve as parish pastors.^{[citation needed]}

The seat of the archbishop is St. Francis de Sales Cathedral in Cape Coast.

Vicars Apostolic of Gold Coast

• Maximilien Albert, S.M.A. (1895-1903)
• Isidore Klaus, S.M.A. (1904-1905)
• François-Ignace Hummel, S.M.A. (1906-1924)
• Ernest Hauger, S.M.A. (1925-1932)

Archbishops of Cape Coast

• William Porter, S.M.A. (1933-1959)
• John Kodwo Amissah (1959-1991)
• Peter Turkson (1992-2009)
• Matthias Kobena Nketsiah (2010-2018)
• Charles G. Palmer-Buckle (2018- )^[3]

Auxiliary Bishops

• John Kodwo Amissah (1957-1959), appointed Archbishop here
• Matthias Kobena Nketsiah (2006-2010), appointed Archbishop here

Other priest of this diocese who became bishop

• Joseph Amihere Essuah, appointed Bishop of Kumasi in 1962

• Sekondi–Takoradi
• Wiawso

• Catholicism in Ghana

5°06′23″N 1°14′41″W / 5.1065°N 1.2446°W / 5.1065; -1.2446