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S1PR4

Summary

Sphingosine-1-phosphate receptor 4 also known as S1PR4 is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P). Hence this receptor is also known as S1P4.[5]

S1PR4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesS1PR4, EDG6, LPC1, S1P4, SLP4, sphingosine-1-phosphate receptor 4
External IDsOMIM: 603751 MGI: 1333809 HomoloGene: 2799 GeneCards: S1PR4
Orthologs
SpeciesHumanMouse
Entrez

8698

13611

Ensembl

ENSG00000125910

ENSMUSG00000044199

UniProt

O95977

Q9Z0L1

RefSeq (mRNA)

NM_003775

NM_010102

RefSeq (protein)

NP_003766

NP_034232

Location (UCSC)Chr 19: 3.17 – 3.18 MbChr 10: 81.33 – 81.34 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function edit

This gene is a member of the endothelial differentiation, G-protein-coupled (EDG) receptor gene family. EDG receptors bind lysophospholipids or lysosphingolipids as ligands, and are involved in cell signalling in many different cell types. This EDG receptor gene is intronless and is specifically expressed in the lymphoid tissue.[5]

Evolution edit

Paralogues to S1PR4 Gene[6] edit

See also edit

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000125910 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000044199 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: S1PR4 Sphingosine-1-phosphate receptor 4".
  6. ^ "Ensembl Genome Browser".

Further reading edit

  • Gräler MH, Bernhardt G, Lipp M (1998). "EDG6, a novel G-protein-coupled receptor related to receptors for bioactive lysophospholipids, is specifically expressed in lymphoid tissue". Genomics. 53 (2): 164–9. doi:10.1006/geno.1998.5491. PMID 9790765.
  • Yamazaki Y, Kon J, Sato K, et al. (2000). "Edg-6 as a putative sphingosine 1-phosphate receptor coupling to Ca(2+) signaling pathway". Biochem. Biophys. Res. Commun. 268 (2): 583–9. doi:10.1006/bbrc.2000.2162. PMID 10679247.
  • Van Brocklyn JR, Gräler MH, Bernhardt G, et al. (2000). "Sphingosine-1-phosphate is a ligand for the G protein-coupled receptor EDG-6". Blood. 95 (8): 2624–9. doi:10.1182/blood.V95.8.2624. PMID 10753843. S2CID 12111192.
  • Idzko M, Panther E, Corinti S, et al. (2002). "Sphingosine 1-phosphate induces chemotaxis of immature and modulates cytokine-release in mature human dendritic cells for emergence of Th2 immune responses". FASEB J. 16 (6): 625–7. doi:10.1096/fj.01-0625fje. PMID 11919175. S2CID 28178637.
  • Kveberg L, Bryceson Y, Inngjerdingen M, et al. (2002). "Sphingosine 1 phosphate induces the chemotaxis of human natural killer cells. Role for heterotrimeric G proteins and phosphoinositide 3 kinases". Eur. J. Immunol. 32 (7): 1856–64. doi:10.1002/1521-4141(200207)32:7<1856::AID-IMMU1856>3.0.CO;2-B. PMID 12115604. S2CID 32001972.
  • Candelore MR, Wright MJ, Tota LM, et al. (2002). "Phytosphingosine 1-phosphate: a high affinity ligand for the S1P(4)/Edg-6 receptor". Biochem. Biophys. Res. Commun. 297 (3): 600–6. doi:10.1016/S0006-291X(02)02237-4. PMID 12270137.
  • Contos JJ, Ye X, Sah VP, Chun J (2002). "Tandem genomic arrangement of a G protein (Gna15) and G protein-coupled receptor (s1p(4)/lp(C1)/Edg6) gene". FEBS Lett. 531 (1): 99–102. doi:10.1016/S0014-5793(02)03409-9. PMID 12401211. S2CID 27266693.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Vogler R, Sauer B, Kim DS, et al. (2003). "Sphingosine-1-phosphate and its potentially paradoxical effects on critical parameters of cutaneous wound healing". J. Invest. Dermatol. 120 (4): 693–700. doi:10.1046/j.1523-1747.2003.12096.x. PMID 12648236.
  • Gräler MH, Grosse R, Kusch A, et al. (2003). "The sphingosine 1-phosphate receptor S1P4 regulates cell shape and motility via coupling to Gi and G12/13". J. Cell. Biochem. 89 (3): 507–19. doi:10.1002/jcb.10537. PMID 12761884. S2CID 2164285.
  • Kyi CS, Key SJ, Lloyd TW (2003). "Use of a nasogastric catheter to prevent soft tissue entanglement of the externally ported distractor arm". International Journal of Oral and Maxillofacial Surgery. 32 (3): 337–8. doi:10.1054/ijom.2003.0364. PMID 12767884.
  • Holdsworth G, Osborne DA, Pham TT, et al. (2005). "A single amino acid determines preference between phospholipids and reveals length restriction for activation of the S1P4 receptor". BMC Biochem. 5: 12. doi:10.1186/1471-2091-5-12. PMC 514652. PMID 15298705.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

External links edit

  • "Lysophospholipid Receptors: S1P4". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-05.
  • Lysophospholipid+receptors at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.