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SERPINA9

Summary

Serpin A9 also known as centerin or GCET1 is a protein that in humans is encoded by the SERPINA9 gene located on chromosome 14q32.1.[5] Serpin A9 is a member of the serpin family of serine protease inhibitors.

SERPINA9
Identifiers
AliasesSERPINA9, GCET1, SERPINA11, SERPINA11b, serpin family A member 9
External IDsOMIM: 615677 MGI: 1919157 HomoloGene: 23633 GeneCards: SERPINA9
Orthologs
SpeciesHumanMouse
Entrez

327657

71907

Ensembl

ENSG00000170054

ENSMUSG00000058260

UniProt

Q86WD7

Q9D7D2

RefSeq (mRNA)

NM_001042518
NM_001284275
NM_001284276
NM_175739

NM_027997
NM_001361910
NM_001361912

RefSeq (protein)

NP_001035983
NP_001271204
NP_001271205
NP_783866

NP_082273
NP_001348839
NP_001348841

Location (UCSC)Chr 14: 94.46 – 94.48 MbChr 12: 103.96 – 103.98 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function edit

The expression of SERPINA9 is restricted to germinal center B cells and lymphoid malignancies. SERPINA9 is likely to function in vivo in the germinal center as an efficient inhibitor of trypsin-like proteases.[6][7][8]

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000170054 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000058260 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: SERPINA9".
  6. ^ Paterson MA, Horvath AJ, Pike RN, Coughlin PB (August 2007). "Molecular characterization of centerin, a germinal centre cell serpin". Biochem. J. 405 (3): 489–94. doi:10.1042/BJ20070174. PMC 2267310. PMID 17447896.
  7. ^ Montes-Moreno S, Roncador G, Maestre L, Martínez N, Sanchez-Verde L, Camacho FI, Cannata J, Martinez-Torrecuadrada JL, Shen Y, Chan WC, Piris MA (January 2008). "Gcet1 (centerin), a highly restricted marker for a subset of germinal center-derived lymphomas". Blood. 111 (1): 351–8. doi:10.1182/blood-2007-06-094151. PMID 17898315.
  8. ^ Paterson MA, Hosking PS, Coughlin PB (July 2008). "Expression of the serpin centerin defines a germinal center phenotype in B-cell lymphomas". Am. J. Clin. Pathol. 130 (1): 117–26. doi:10.1309/9QKE68QU7B825A3U. PMID 18550480.

Further reading edit

  • Luke MM, O'Meara ES, Rowland CM, et al. (2009). "Gene variants associated with ischemic stroke: the cardiovascular health study". Stroke. 40 (2): 363–8. doi:10.1161/STROKEAHA.108.521328. PMC 2881155. PMID 19023099.
  • Frazer JK, Jackson DG, Gaillard JP, et al. (2000). "Identification of centerin: a novel human germinal center B cell-restricted serpin". Eur. J. Immunol. 30 (10): 3039–48. doi:10.1002/1521-4141(200010)30:10<3039::AID-IMMU3039>3.0.CO;2-H. PMID 11069088.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Morrison AC, Bare LA, Luke MM, et al. (2008). "Single nucleotide polymorphisms associated with coronary heart disease predict incident ischemic stroke in the atherosclerosis risk in communities study". Cerebrovasc. Dis. 26 (4): 420–4. doi:10.1159/000155637. PMC 2662496. PMID 18799872.
  • Shiffman D, O'Meara ES, Bare LA, et al. (2008). "Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study". Arterioscler. Thromb. Vasc. Biol. 28 (1): 173–9. doi:10.1161/ATVBAHA.107.153981. PMC 2636623. PMID 17975119.
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Montes-Moreno S, Roncador G, Maestre L, et al. (2008). "Gcet1 (centerin), a highly restricted marker for a subset of germinal center-derived lymphomas". Blood. 111 (1): 351–8. doi:10.1182/blood-2007-06-094151. PMID 17898315.
  • Pan Z, Shen Y, Du C, et al. (2003). "Two newly characterized germinal center B-cell-associated genes, GCET1 and GCET2, have differential expression in normal and neoplastic B cells". Am. J. Pathol. 163 (1): 135–44. doi:10.1016/S0002-9440(10)63637-1. PMC 1868163. PMID 12819018.
  • Namciu SJ, Friedman RD, Marsden MD, et al. (2004). "Sequence organization and matrix attachment regions of the human serine protease inhibitor gene cluster at 14q32.1". Mamm. Genome. 15 (3): 162–78. doi:10.1007/s00335-003-2311-y. PMID 15014966. S2CID 8594824.

External links edit

  • The MEROPS online database for peptidases and their inhibitors: I04.082
  • SERPINA9+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)