Serpin peptidase inhibitor, clade B (ovalbumin), member 10 is a protein that in humans is encoded by the SERPINB10 gene.[5]
SERPINB10 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | SERPINB10, PI-10, PI10, serpin family B member 10 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 602058 MGI: 2138648 HomoloGene: 68430 GeneCards: SERPINB10 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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The superfamily of high molecular weight serine proteinase inhibitors (serpins) regulate a diverse set of intracellular and extracellular processes such as complement activation, fibrinolysis, coagulation, cellular differentiation, tumor suppression, apoptosis, and cell migration. Serpins are characterized by a well-conserved tertiary structure that consists of 3 beta sheets and 8 or 9 alpha helices.[6] A critical portion of the molecule, the reactive center loop connects beta sheets A and C. Protease inhibitor-10 (PI10; SERPINB10) is a member of the ov-serpin subfamily, which, relative to the archetypal serpin PI1, is characterized by a high degree of homology to chicken ovalbumin, lack of N- and C-terminal extensions, absence of a signal peptide, and a serine rather than an asparagine residue at the penultimate position.[7]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.