SERPINB7 Knowpia

SERPINB7
Identifiers
Aliases	SERPINB7, MEGSIN, PPKN, TP55, serpin family B member 7
External IDs	OMIM: 603357 MGI: 2151053 HomoloGene: 68363 GeneCards: SERPINB7
Gene location (Human)
Chr.	Chromosome 18 (human)
End	63,805,376 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	107,380,419 bp
RNA expression pattern
	Top expressed in
	human penis; ; skin of abdomen; ; vulva; ; bronchial epithelial cell; ; nipple; ; amniotic fluid; ; islet of Langerhans; ; stromal cell of endometrium; ; oral cavity; ; gums;
	Top expressed in
	belly cord; ; skin of abdomen; ; skin of back; ; olfactory epithelium; ; lip; ; esophagus; ; condyle; ; fossa; ; cervix; ; sexually immature organism;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase inhibitor activity; serine-type endopeptidase inhibitor activity;
Cellular component	cytoplasm; extracellular space;
Biological process	positive regulation of collagen biosynthetic process; positive regulation of transforming growth factor beta1 production; negative regulation of peptidase activity; positive regulation of glomerular mesangial cell proliferation; positive regulation of platelet-derived growth factor production; negative regulation of endopeptidase activity;
	Sources:Amigo / QuickGO
Orthologs
	8710
	116872
	ENSG00000166396
	ENSMUSG00000067001
	O75635
	Q9D695
	NM_001040147; NM_001261830; NM_001261831; NM_003784
	NM_027548
	NP_001035237; NP_001248759; NP_001248760; NP_003775
	NP_081824
	Wikidata
View/Edit Human	View/Edit Mouse

Serpin B7 is a protein that in humans is encoded by the SERPINB7 gene.^[5]

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000166396 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000067001 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7".

Further reading edit

Tsujimoto M, Tsuruoka N, Ishida N, et al. (1997). "Purification, cDNA cloning, and characterization of a new serpin with megakaryocyte maturation activity". J. Biol. Chem. 272 (24): 15373–80. doi:10.1074/jbc.272.24.15373. PMID 9182567.
Miyata T, Nangaku M, Suzuki D, et al. (1998). "A mesangium-predominant gene, megsin, is a new serpin upregulated in IgA nephropathy". J. Clin. Invest. 102 (4): 828–36. doi:10.1172/JCI2450. PMC 508946. PMID 9710452.
Inagi R, Miyata T, Suzuki D, et al. (2001). "Specific tissue distribution of megsin, a novel serpin, in the glomerulus and its up-regulation in IgA nephropathy". Biochem. Biophys. Res. Commun. 286 (5): 1098–106. doi:10.1006/bbrc.2001.5509. PMID 11527413.
Inagi R, Miyata T, Imasawa T, et al. (2003). "Mesangial cell-predominant gene, megsin". Nephrol. Dial. Transplant. 17 Suppl 9 (90009): 32–3. doi:10.1093/ndt/17.suppl_9.32. PMID 12386281.
Inagi R, Miyata T, Nangaku M, et al. (2003). "Transcriptional regulation of a mesangium-predominant gene, megsin" (PDF). J. Am. Soc. Nephrol. 13 (11): 2715–22. doi:10.1097/01.ASN.0000033507.32175.FA. PMID 12397041.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Li YJ, Du Y, Li CX, et al. (2004). "Family-based association study showing that immunoglobulin A nephropathy is associated with the polymorphisms 2093C and 2180T in the 3' untranslated region of the Megsin gene". J. Am. Soc. Nephrol. 15 (7): 1739–43. doi:10.1097/01.ASN.0000130858.00688.46. PMID 15213261.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Inagi R, Nangaku M, Usuda N, et al. (2005). "Novel serpinopathy in rat kidney and pancreas induced by overexpression of megsin". J. Am. Soc. Nephrol. 16 (5): 1339–49. doi:10.1681/ASN.2004070600. PMID 15788472.
Xia Y, Li Y, Du Y, et al. (2006). "Association of MEGSIN 2093C-2180T haplotype at the 3' untranslated region with disease severity and progression of IgA nephropathy". Nephrol. Dial. Transplant. 21 (6): 1570–4. doi:10.1093/ndt/gfk096. PMID 16431886.
Xia YF, Huang S, Li X, et al. (2006). "A family-based association study of megsin A23167G polymorphism with susceptibility and progression of IgA nephropathy in a Chinese population". Clin. Nephrol. 65 (3): 153–9. doi:10.5414/cnp65153. PMID 16550745.

External links edit

The MEROPS online database for peptidases and their inhibitors: I04.012
SERPINB7+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000166396 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000067001 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7".

[5]

[1]

[2]

[3]

[4]

Summary

See also edit

References edit

Further reading edit

External links edit