SIRPG Knowpia

SIRPG
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2JJW, 4I2X
Identifiers
Aliases	SIRPG, CD172g, SIRP-B2, SIRPB2, SIRPgamma, bA77C3.1, signal regulatory protein gamma
External IDs	OMIM: 605466 HomoloGene: 56809 GeneCards: SIRPG
Gene location (Human)
Chr.	Chromosome 20 (human)
End	1,657,779 bp
RNA expression pattern
	Top expressed in
	lymph node; ; blood; ; appendix; ; spleen; ; thymus; ; rectum; ; bone marrow cells; ; gallbladder; ; pharynx; ; thymus;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	integral component of membrane; plasma membrane; membrane; intracellular anatomical structure;
Biological process	cell-cell signaling; cell adhesion; intracellular signal transduction; positive regulation of T cell activation; leukocyte migration; positive regulation of cell population proliferation; negative regulation of cell population proliferation; positive regulation of cell-cell adhesion; positive regulation of phagocytosis;
	Sources:Amigo / QuickGO
Orthologs
	55423
	n/a
	ENSG00000089012
	n/a
	Q9P1W8
	n/a
	NM_001039508; NM_018556; NM_080816
	n/a
	NP_001034597; NP_061026; NP_543006
	n/a
	Wikidata
View/Edit Human

Signal-regulatory protein gamma is a protein that in humans is encoded by the SIRPG gene.^[3]^[4]^[5] SIRPG has also recently been designated CD172G (cluster of differentiation 172G).

The protein encoded by this gene is a member of the signal-regulatory protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Alternatively spliced transcript variants encoding different isoforms have been described.^[5]

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000089012 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ichigotani Y, Matsuda S, Machida K, Oshima K, Iwamoto T, Yamaki K, Hayakawa T, Hamaguchi M (Jan 2001). "Molecular cloning of a novel human gene (SIRP-B2) which encodes a new member of the SIRP/SHPS-1 protein family". J Hum Genet. 45 (6): 378–82. doi:10.1007/s100380070013. PMID 11185750.
^ van den Berg TK, van Beek EM, Buhring HJ, Colonna M, Hamaguchi M, Howard CJ, Kasuga M, Liu Y, Matozaki T, Neel BG, Parkos CA, Sano S, Vignery A, Vivier E, Wright M, Zawatzky R, Barclay AN (Dec 2005). "A nomenclature for signal regulatory protein family members". J Immunol. 175 (12): 7788–9. doi:10.4049/jimmunol.175.12.7788. PMID 16339511.
^ ^a ^b "Entrez Gene: SIRPG signal-regulatory protein gamma".