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SN-2

Summary

SN-2 is a chemical compound which acts as an "agonist" (i.e. channel opener) for the TRPML3 calcium channel, with high selectivity for TRPML3 and no significant activity at the related TRPML1 and TRPML2 channels.[1] It has demonstrated antiviral activity in an in vitro model.[2]

SN-2
Identifiers
  • 5-(2,4,6-trimethylphenyl)-3-oxa-4-azatricyclo[5.2.1.02,6]dec-4-ene
CAS Number
  • 823218-99-1 checkY
PubChem CID
  • 11834987
UNII
  • R4LCV6XQR7
Chemical and physical data
FormulaC17H21NO
Molar mass255.361 g·mol−1
3D model (JSmol)
  • Interactive image
  • CC1=CC(=C(C(=C1)C)C2=NOC3C2C4CCC3C4)C
  • InChI=1S/C17H21NO/c1-9-6-10(2)14(11(3)7-9)16-15-12-4-5-13(8-12)17(15)19-18-16/h6-7,12-13,15,17H,4-5,8H2,1-3H3
  • Key:WKLZNTYMDOPBSE-UHFFFAOYSA-N

See also edit

References edit

  1. ^ Grimm C, Jörs S, Saldanha SA, Obukhov AG, Pan B, Oshima K, et al. (February 2010). "Small molecule activators of TRPML3". Chemistry & Biology. 17 (2): 135–48. doi:10.1016/j.chembiol.2009.12.016. PMC 2834294. PMID 20189104.
  2. ^ Xia Z, Wang L, Li S, Tang W, Sun F, Wu Y, et al. (October 2020). "ML-SA1, a selective TRPML agonist, inhibits DENV2 and ZIKV by promoting lysosomal acidification and protease activity". Antiviral Research. 182: 104922. doi:10.1016/j.antiviral.2020.104922. PMID 32858116. S2CID 221365410.