STEAP2 Knowpia

STEAP2
Identifiers
Aliases	STEAP2, IPCA1, PCANAP1, PUMPCn, STAMP1, STMP, STEAP2 metalloreductase
External IDs	OMIM: 605094 MGI: 1921301 HomoloGene: 17682 GeneCards: STEAP2
Gene location (Human)
Chr.	Chromosome 7 (human)
End	90,238,137 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	5,744,578 bp
RNA expression pattern
	Top expressed in
	pericardium; ; Achilles tendon; ; prostate; ; Brodmann area 23; ; middle temporal gyrus; ; pancreatic epithelial cell; ; cerebellar vermis; ; superior frontal gyrus; ; postcentral gyrus; ; synovial joint;
	Top expressed in
	oocyte; ; secondary oocyte; ; kidney; ; olfactory epithelium; ; ciliary body; ; iris; ; medial vestibular nucleus; ; pontine nuclei; ; adrenal gland; ; otolith organ;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transporter activity; metal ion binding; cupric reductase activity; ferric-chelate reductase (NADPH) activity; oxidoreductase activity;
Cellular component	integral component of membrane; integral component of Golgi membrane; cytosol; endosome; membrane; plasma membrane; early endosome; trans-Golgi network transport vesicle; endosome membrane; integral component of plasma membrane;
Biological process	endocytosis; iron ion homeostasis; copper ion import; ion transport; response to hormone; regulated exocytosis; Golgi to plasma membrane transport; iron ion import across cell outer membrane;
	Sources:Amigo / QuickGO
Orthologs
	261729
	74051
	ENSG00000157214
	ENSMUSG00000015653
	Q8NFT2
	Q8BWB6
NM_001040665; NM_001040666; NM_001244944; NM_001244945; NM_001244946;
	NM_152999
NM_001103156; NM_001103157; NM_001285469; NM_001285470; NM_001285471;
	NM_028734
NP_001035755; NP_001035756; NP_001231873; NP_001231874; NP_001231875;
	NP_694544
NP_001096626; NP_001096627; NP_001272398; NP_001272399; NP_001272400;
	NP_083010
	Wikidata
View/Edit Human	View/Edit Mouse

Metalloreductase STEAP2 is an enzyme that in humans is encoded by the STEAP2 gene.^[5]^[6]^[7]

This gene is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi complex, the plasma membrane, and the vesicular tubular structures in the cytosol.

A highly similar protein in mouse has both ferri reductase and cupric reductase activity, and stimulates the cellular uptake of both iron and copper in vitro. Increased transcriptional expression of the human gene is associated with prostate cancer progression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[7]

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000157214 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000015653 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Walker MG, Volkmuth W, Sprinzak E, Hodgson D, Klingler T (Jan 2000). "Prediction of Gene Function by Genome-Scale Expression Analysis: Prostate Cancer-Associated Genes". Genome Res. 9 (12): 1198–203. doi:10.1101/gr.9.12.1198. PMC 310991. PMID 10613842.
^ Korkmaz KS, Elbi C, Korkmaz CG, Loda M, Hager GL, Saatcioglu F (Sep 2002). "Molecular cloning and characterization of STAMP1, a highly prostate-specific six transmembrane protein that is overexpressed in prostate cancer". J Biol Chem. 277 (39): 36689–96. doi:10.1074/jbc.M202414200. PMID 12095985.
^ ^a ^b "Entrez Gene: STEAP2 six transmembrane epithelial antigen of the prostate 2".

Further reading edit

Denoeud F, Kapranov P, Ucla C, et al. (2007). "Prominent use of distal 5′ transcription start sites and discovery of a large number of additional exons in ENCODE regions". Genome Res. 17 (6): 746–59. doi:10.1101/gr.5660607. PMC 1891335. PMID 17567994.
Ohgami RS, Campagna DR, McDonald A, Fleming MD (2006). "The Steap proteins are metalloreductases". Blood. 108 (4): 1388–94. doi:10.1182/blood-2006-02-003681. PMC 1785011. PMID 16609065.
Korkmaz CG, Korkmaz KS, Kurys P, et al. (2005). "Molecular cloning and characterization of STAMP2, an androgen-regulated six transmembrane protein that is overexpressed in prostate cancer". Oncogene. 24 (31): 4934–45. doi:10.1038/sj.onc.1208677. PMID 15897894.
Sanchez-Pulido L, Rojas AM, Valencia A, et al. (2005). "ACRATA: a novel electron transfer domain associated to apoptosis and cancer". BMC Cancer. 4: 98. doi:10.1186/1471-2407-4-98. PMC 546010. PMID 15623366.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Porkka KP, Helenius MA, Visakorpi T (2002). "Cloning and characterization of a novel six-transmembrane protein STEAP2, expressed in normal and malignant prostate". Lab. Invest. 82 (11): 1573–82. doi:10.1097/01.lab.0000038554.26102.c6. PMID 12429817.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000157214 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000015653 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10613842-5] Walker MG, Volkmuth W, Sprinzak E, Hodgson D, Klingler T (Jan 2000). "Prediction of Gene Function by Genome-Scale Expression Analysis: Prostate Cancer-Associated Genes". Genome Res. 9 (12): 1198–203. doi:10.1101/gr.9.12.1198. PMC 310991. PMID 10613842.

[pmid12095985-6] Korkmaz KS, Elbi C, Korkmaz CG, Loda M, Hager GL, Saatcioglu F (Sep 2002). "Molecular cloning and characterization of STAMP1, a highly prostate-specific six transmembrane protein that is overexpressed in prostate cancer". J Biol Chem. 277 (39): 36689–96. doi:10.1074/jbc.M202414200. PMID 12095985.

[entrez-7] "Entrez Gene: STEAP2 six transmembrane epithelial antigen of the prostate 2".

[5]

[6]

[7]

[1]

[2]

[3]

[4]

Summary

References edit

Further reading edit