Safiye Sultan may refer to:

• Safiye Sultan (mother of Mehmed III) (1550–1619), Ottoman imperial consort of Sultan Murad III, and mother and Valide Sultan of Sultan Mehmed III
• Safiye Hanımsultan (daughter of Ismihan Sultan) (1563 - ?), daughter of Ismihan Sultan
• Safiye Hanımsultan (1581–?), Ottoman princess, daughter of Ayşe Hümaşah Sultan
• Safiye Hanımsultan (1630-1682), Ottoman princess, daughter of Gevherhan Sultan
• Safiye Sultan (daughter of Murad IV) (after 1634–1680 or after), Ottoman princess, daughter of Sultan Murad IV
• Safiye Sultan, Ottoman princess (1640–?), daughter of Sultan Ibrahim
• Safiye Sultan (daughter of Mustafa II) (1696–1778), Ottoman princess, daughter of Sultan Mustafa II
• Safiye Sultan (1887–?), Ottoman princess, daughter of Şehzade Mehmed Selaheddin