Saint-Jean-Baptiste is a neighbourhood of Quebec City, which is the capital of the province of Quebec in Canada. Located immediately west of Old Quebec, it is known for its shopping and restaurants.

The Rue Saint Jean is the principal street in the district from (Avenue de Salaberry to Autoroute 175) with many independent cafes, bars and specialist grocery stores.

Along with Old Quebec, and Saint-Roch it forms the oldest part of the city. When the old city wall existed, the area was just west of the Port Saint Louis. Maps in 1776 have the area called Suburb or St John dotted with small hills and homes outside of the city walls.

On 28 June 1845 it was the site of the Second 1845 Quebec Fire (but not to be mistaken with the Great Fire of Quebec City) when the areas were called St. Jean.