Saint-Zacharie is a municipality in the Municipalité régionale de comté des Etchemins in Quebec, Canada. It is part of the Chaudière-Appalaches region and the population is 1,684 as of 2021. The new constitution dates from 1990, when the township municipality and the village municipality of Saint-Zacharie amalgamated, but the area was settled as early as 1873. Saint-Zacharie is named after oblate Zacharie Lacasse, a missionary who brought settlers to the area in 1881.

Saint-Zacharie
Municipality
The church in 1910.
Location within Les Etchemins RCM.
Saint-Zacharie Location in southern Quebec.
Coordinates: 46°08′N 70°22′W / 46.133°N 70.367°W / 46.133; -70.367[1]
Country	Canada
Province	Quebec
Region	Chaudière-Appalaches
RCM	Les Etchemins
Constituted	April 18, 1990
Government [2]
• Mayor	Joey Cloutier
• Federal riding	Beauce
• Prov. riding	Beauce-Sud
Area [2][3]
• Total	188.80 km2 (72.90 sq mi)
• Land	186.56 km2 (72.03 sq mi)
Population  (2021)[3]
• Total	1,684
• Density	9/km2 (20/sq mi)
• Pop 2016-2021	1.9%
• Dwellings	825
Time zone	UTC−5 (EST)
• Summer (DST)	UTC−4 (EDT)
Postal code(s)	G0M 2C0
Area code(s)	418 and 581
Highways	R-275
Website	www.st-zacharie.qc.ca

Saint-Zacharie is located on the Canada–United States border and has a small border crossing for traffic coming from the United States, St. Zacharie Crossing.