Saint Jerome in His Study is a c. 1445–1446 painting by Colantonio, a painter active in Naples between 1440 and around 1470. It shows the strong influence of contemporary Flemish and French art on the painter and originally formed part of a multi-panel altarpiece for the church of San Lorenzo Maggiore, later split up. The painting's dimensions are 151 centimetres (59 in) by 178 centimetres (70 in).

Saint Jerome In His Study
Italian: San Girolamo nello studio
Artist	Colantonio
Year	c. 1445–1446
Dimensions	151 cm (59 in) × 178 cm (70 in)
Location	Museo di Capodimonte

The work is now in the National Museum of Capodimonte.