Salted versions of both fission and fusion weapons can be made by surrounding the core of the explosive device with a material containing an element that can be converted to a highly radioactive isotope by neutron bombardment.^[1] When the bomb explodes, the element absorbs neutrons released by the nuclear reaction, converting it to its radioactive form. The explosion scatters the resulting radioactive material over a wide area, leaving it uninhabitable far longer than an area affected by typical nuclear weapons. In a salted hydrogen bomb, the radiation case around the fusion fuel, which normally is made of some fissionable element, is replaced with a metallic salting element. Salted fission bombs can be made by replacing the neutron reflector between the fissionable core and the explosive layer with a metallic element. The energy yield from a salted weapon is usually lower than from an ordinary weapon of similar size as a consequence of these changes.

The radioactive isotope used for the fallout material would be a high-intensity gamma ray emitter, with a half-life long enough that it remains lethal for an extended period. It would also have to have a chemistry that causes it to return to earth as fallout, rather than stay in the atmosphere after being vaporized in the explosion. Another consideration is biological: radioactive isotopes of elements normally taken up by plants and animals as nutrition would pose a special threat to organisms that absorbed them, as their radiation would be delivered from within the body of the organism.

Radioactive isotopes that have been suggested for salted bombs include gold-198, tantalum-182, zinc-65, and cobalt-60.^[1] Sodium-23, the only stable isotope, has also been proposed as a casing for a salted bomb. Neutron flux would activate it to ²⁴
Na, which would produce intense gamma-ray emissions for several days after the detonation.^[5][6] Physicist W. H. Clark looked at the potential of such devices and estimated that a 20 megaton bomb salted with sodium would generate sufficient radiation to contaminate 200,000 square miles (520,000 km²) (an area that is slightly larger than Spain or Thailand, though smaller than France). Given the intensity of the gamma radiation, not even those in basement shelters could survive within the fallout zone.^[7] However, the short half-life of sodium-24 (15 h)^[8]: 25 would mean that the radiation would not spread far enough to be a true doomsday weapon.^[7][9]

A cobalt bomb was first suggested by Leo Szilard in 1950. He publicly sounded the alarm against the possible development of salted thermonuclear bombs capable of annihilating mankind on a University of Chicago Round Table radio program.^[10][11] His comments, as well as those of Hans Bethe, Harrison Brown, and Frederick Seitz (the three other scientists who participated in the program), were attacked by the Atomic Energy Commission's former Chairman David Lilienthal, and the criticisms plus a response from Szilard were published.^[11] Time compared Szilard to Chicken Little while the AEC dismissed his ideas, but scientists debated whether it was feasible or not.^[9] The Bulletin of the Atomic Scientists commissioned a study by James R. Arnold, who concluded that it was.^[12] In his 1961 essay, Clark suggested that a 50 megaton cobalt bomb did have the potential to produce sufficient long-lasting radiation to be a doomsday weapon, in theory, but was of the view that, even then, "enough people might find refuge to wait out the radioactivity and emerge to begin again."^[7][9]

• In Nevil Shute's novel On the Beach (1957), cobalt bombs are mentioned as the cause of the lethal radioactivity that is approaching Australia. The cobalt bomb was a symbol of man's hubris.^[13]
• In City of Fear (1959), an escaped convict from San Quentin State Prison steals a canister of cobalt-60, thinking it contains drugs. He flees to Los Angeles to pawn it, not knowing it could kill him and possibly contaminate the city.
• In the dark comedy Dr. Strangelove, or: How I Learned to Stop Worrying and Love the Bomb (1964), a type of cobalt-salted bomb is employed, specifically utilizing a composite called 'Cobalt-Thorium G' with a Dead Hand mechanism, by the Soviet Union as a 'doomsday device' nuclear deterrent: if the system detects any nuclear attack, the doomsday device will be automatically unleashed. With unfortunate timing, a deranged American general mutinies and orders an attack on the USSR before the Soviet secret device, already activated, could be unveiled to the world. One American bomber piloted by a hapless and unknowing crew gets through to their target; the Dead Hand mechanism works as designed and initiates a worldwide nuclear holocaust. In the film, the Soviet Ambassador says, "If you take, say, fifty H-bombs in the hundred megaton range and jacket them with Cobalt-Thorium G, when they are exploded they will produce a doomsday shroud. A lethal cloud of radioactivity which will encircle the earth for ninety-three years!"^[14]
• In the James Bond film Goldfinger (1964), the title character informs Bond he intends to set off a "particularly dirty" atomic device using "cobalt and iodine"^[15] in the U.S. Bullion Depository at Fort Knox as part of Operation Grand Slam, a scheme intended to contaminate the gold at Fort Knox to increase value of the gold he has been stockpiling.
• In Roger Zelazny's 1965 Hugo Award–winning novel This Immortal, Earth has suffered a nuclear war many decades ago and some areas still suffer high radiation levels from cobalt bombs, leading to drastic mutations and ecological changes.
• In the fourth act of the classic Star Trek episode "Obsession" (1967), Ensign Garrovick refers to 10,000 cobalt bombs not equaling the power of less than one ounce of antimatter.
• In Beneath the Planet of the Apes (1970) the main character, upon seeing that an underground mutant community worship a doomsday bomb, comments "They finally built one with a cobalt casing" in reference to a cobalt bomb that could wipe out the world. After astronauts Brent and Taylor are shot by an invading army of apes, Taylor's dying act is to detonate the doomsday bomb, obliterating all life on fortieth century Earth.
• In Tom Clancy's novel The Sum of All Fears (1991) it is noted that Israeli Air Force tactical nuclear bombs can optionally be fitted with cobalt jackets "to poison a landscape to all kinds of life for years to come".^[16]
• In the video game Metro Exodus (2019), the player visits the Russian city of Novosibirsk which was hit with at least one cobalt warhead during a worldwide nuclear war in the year 2013, resulting in catastrophic levels of radiation, and is the most irradiated area visited in the three Metro games.
• In the video game Detroit: Become Human (2018), the player has the option of detonating an improvised cobalt bomb during certain endings of the game. The detonation of the bomb results in humans evacuating the now-irradiated city of Detroit and the area 50 miles around, though promising to retake it from the androids in the future. Depending on the player's actions, the city is left empty or the androids claim it for their own.
• In a two-part episode of the TV show The Bionic Woman, "Doomsday Is Tomorrow", a cobalt bomb, dubbed by its creator as "the most diabolical instrument of destruction ever conceived by man," is used as a trigger for a more powerful weapon that can render the world lifeless.

• Doomsday device
• Fail-deadly