Samuel or Sam Greene may refer to:

• Samuel Greene (naval officer) (1839–1884), United States Navy officer
• Samuel Harrison Greene (1845–1920), American Baptist pastor, church leader, and university official
• Samuel Thomas Greene (1843–1890), American educator of the deaf
• Samuel Stillman Greene (1810–1883), American educator
• Sam Greene (sportswriter) (1895–1963), American sportswriter
• Sam Greene (rugby union) (born 1994), Australian rugby union player
• Sam Greene (academic), professor in Russian politics