San Francisco 49ers, a professional American football club located in Santa Clara, California, but retains the name San Francisco, having played in the city from 1946 to 2013
San Francisco City FC, an American amateur soccer club located in San Francisco, California
San Francisco Dons, the nickname of the athletic teams at the University of San Francisco
San Francisco F.C., a Panamanian football club located in La Chorrera, Panamá
San Francisco Giants, a professional baseball club located in San Francisco, California