A church at this site, built on an Isis dedicated Roman temple, was consecrated in 421, and for four centuries was the burial site for the bishops of Verona.^[1] For a time, this served as cathedral of the city. The church was partially damaged during the earthquake of 1117. It was subsequently reconstructed in Romanesque style.

The façade is made up of rows of soft stone and brick. During the 10th-century, the crypt was built. The four central dark granite columns are of Egyptian origin. The octagonal lantern with a double row of mullioned windows is an example of Lombard Romanesque. The belltower contains six bells in F#, hung for Veronese bellringing art^[2]

The two-storey apse has elements from the early Christian era and from the early Middle Ages.

An inventory of 1750 noted the main altarpiece and the choir were decorated by Domenico Brusasorzi.^[3] Martino da Verona's Annunciation and Coronation of the Virgin is located in the left transept. The Tribune was frescoed by Bernardo Muttoni. Some figure above the main altar were painted by Santo Prunati; however the ceiling and the cupola frescoes were mainly by Brusasorzi. He also painted an Adoration of the Magi for the first altar to right. The next altar on the right had a work by Giulio Carpioni the younger, a relative of Giulio Carpioni.

The "Chapel of the Innocents" was commissioned around 1618 by the parish priest, Monsignor Varalli. It was built in Baroque style along the southern wall to the right of the entrance. It has an altarpiece depicting the Massacre of Innocents by Pasquale Ottino and a Martyrdom of 40 martyrs by Alessandro Turchi (L'Orbetto). There are also frescoes by Marcantonio Bassetti, and an Annuciation and frescoes of San Carlo and St Francis by Ottino.

The first altar on the left had a canvas depicting the Virgin and Child with Saints Peter and Andrew by Giovanni Francesco Caroto. To the sides of this altarpiece were paintings of Melchisidech and the Sacrifice of Isaac by Francesco Barbieri. The second altar had a Virgin and Child with Saints Jerome, Francis, Mauro, Simplicio, and Placido by Niccolo Giolfino. A frescoed lunette was competed by Giovanni Battista dal Moro.

In the last altar on left is a Virgin and Child with Saints Joseph, John the Baptist, Francis, and Anthony of Padua by Alessandro Marchesini, and a Virgin and Child with Saints Vicenzo, Stefano, Anthony Abbot, and Francesco di Paola by Santo Prunati. Next to that altar was a Holy Spirit descends among the Apostles by Orazio Farinati.^[4]

The crypt has frescoes by Giulio Carpioni younger (Visitation and Repose in Egypt); Paolo Cimengoli (Annunciation);^[5] and Santo Prunati (Nativity), it held a copy of Raphael.^[6]

45°26′56″N 11°00′00″E / 45.4488°N 11.0000°E / 45.4488; 11.0000