Keyworth was born in Nottingham in 1993^{[1][better source needed][2][better source needed][3][better source needed]} and used to create shows with their brother when they were children.^[4]

Keyworth studied drama at De Montfort University in Leicester from 2011 to 2014 and was active in the university's comedy club,^[5][6] citing Jennifer Saunders as their favourite comedian.^[7]

Keyworth later got a marketing internship at the London Academy of Music and Dramatic Art (LAMDA) and worked as a nanny.^[8]

Keyworth emerged as a runner-up at the 2015 Funny Women^[9] and their first show, Dark Horse, was nominated for best newcomer at the 2018 Edinburgh Comedy Awards.^[10]

They were named Newcomer of the Year at the 2019 Chortle Awards.^[11] Their second show, Pacific, debuted in 2019.^[12][13] An exploration of gender and roles in relationships, Veronica Lee in The Arts Desk described it as a "nicely paced, sharply written and well delivered hour with some great gags".^[14]

On TV and radio, Keyworth has appeared on Roast Battle, The Stand Up Sketch Show, The Now Show, The Dog Ate My Homework, Mock the Week, 8 Out of 10 Cats and Richard Osman's House of Games.^{[15][deprecated source]} In 2019 they performed at the Glastonbury Festival^[4][16] and later that year won the reality TV series Celebrity Coach Trip with friend Francis Boulle of Made in Chelsea ^[17]

Keyworth developed a third show titled Lil' Keys, Big Jokes; they were due to perform the show at the Edinburgh Festival Fringe that year but the Covid-19 pandemic led to the cancellation of the show and almost the entire fringe.^[4][18] In the lockdown that followed the spread of the Covid-19 virus in the UK, Keyworth and Catherine Bohart hosted a weekly online comedy show, 'Gigless'.^[19] Also in 2020, Keyworth created a four-part comedy series for BBC Radio 4, titled Are You a Boy or a Girl?, which explored gender fluidity. It was recorded with a virtual audience over Zoom, and broadcast in November.^[20][21]

In 2021, they appeared on BBC's Live at the Apollo^[22] and in August 2022 Keyworth's third show, Lost Boy, debuted at the Edinburgh Fringe.^[4]

Keyworth lives in London.^[23] They dated Irish comedian Catherine Bohart from 2015 to 2020, during which time they lived together in London's Kilburn area.^[24][25][26] They are non-binary and use she/he/they/them pronouns.^{[4][27][28][29]}

• Official website
• Sarah Keyworth at IMDb