...seeks to elucidate the principles of protein structure evolution, higher order protein structure and protein folding, and the principles underlying protein complex formation and organization. We have a longstanding interest in understanding gene expression regulation, and in our wetlab at the Sanger Institute use mouse T helper cells as a model of cell differentiation.[36]
Sarah Teichmann is Research Group Leader at EMBL-European Bioinformatics Institute and has made major contributions to biology over the past 15 years. A fundamental discovery was her work to define key biophysical mechanisms in protein complex assembly, showing that protein complexes assemble via distinct, ordered pathways. She showed that these assembly pathways are conserved in evolution and how they may be predicted from 3D structure. Her databases and computational analysis methods have had a broad and deep impact on the community. She represents a new breed of scientists at the interface between computational and experimental molecular biology.[15]
Teichmann has also been an activist for women's careers in science through enabling scientists in families to advance their careers while working part-time.[52] She chaired a Sex in Science debate at the Wellcome Trust on balancing family life with working in research.[citation needed] Teichmann was elected an ISCB Fellow in 2016 by the International Society for Computational Biology.[6]
Teichmann has two daughters.[12][14] Teichmann is the co-author of the children's language education novel Teenage Detectives,[56] which she wrote as a teenager together with her mother Dr. Virginia Teichmann, an English-language university lecturer in Karlsruhe.[57]
Referencesedit
Scholia has an author profile for Sarah Teichmann.
^Perica, Tina; Marsh, Joseph A.; Sousa, Filipa L.; Natan, Eviatar; Colwell, Lucy J.; Ahnert, Sebastian E.; Teichmann, Sarah A. (2012). "The emergence of protein complexes: quaternary structure, dynamics and allostery". Biochemical Society Transactions. 40 (3): 475–491. doi:10.1042/BST20120056. PMID 22616857. S2CID 21452774.
^ ab"Dr Sarah Teichmann, EMBL-European Bioinformatics Institute & Wellcome Trust Sanger Institute". lister-institute.org.uk. Archived from the original on 15 October 2014.
^ ab"Sarah A. Teichmann EBI, Cambridge (Hinxton), United Kingdom EMBO 2012". European Molecular Biology Organization. Archived from the original on 19 January 2016.
^"Finding patterns in genes and proteins: decoding the logic of molecular interactions". Royal Society. 2012. Archived from the original on 10 November 2012.
^Finding patterns in genes and proteins: decoding the logic of molecular interactions on YouTube, Royal Society
^ abc"People & Groups: Sarah Teichmann, Group Leader - Teichmann research group". EMBL-EBI. 2013. Archived from the original on 3 April 2013.
^Park, J; Teichmann, S. A.; Hubbard, T; Chothia, C (1997). "Intermediate sequences increase the detection of homology between sequences". Journal of Molecular Biology. 273 (1): 349–54. doi:10.1006/jmbi.1997.1288. PMID 9367767. S2CID 28606158.
^ abMohan, Madan Babu (2004). Evolution of transcriptional regulatory networks. jisc.ac.uk (PhD thesis). University of Cambridge. OCLC 890159758. EThOS uk.bl.ethos.616113.
^ abcTeichmann, Sarah (2007). "Sarah Amalia Teichmann PhD MA BA (Hons cantab) CV" (PDF). mrc-lmb.cam.ac.uk. Laboratory of Molecular Biology. Archived from the original (PDF) on 26 February 2013.
^ abGreenstreet, Rosanna (2018). "Sarah Teichmann: 'I wake as early as 4am and think about work'". The Guardian. London.
^Marx, Vivien (2014). "The Author File: Janet Thornton". Nature Methods. 11 (2): 115. doi:10.1038/nmeth.2831. PMID 24645189. S2CID 1970327.
^ abPain, Elisabeth (2015). "Harnessing computer power to understand biology". Science. doi:10.1126/science.caredit.a1500172.
^ abAnon (2015). "Dr Sarah Teichmann FMedSci". acmedsci.ac.uk. London: Academy of Medical Sciences. Archived from the original on 6 July 2015.
^ ab"Dr Sarah Teichmann, FMedSci, Head of Cellular Genetics". Cambridge: sanger.ac.uk. Archived from the original on 15 April 2016.
^ abMarx, Vivien (2016). "The Author File: Sarah Teichmann". Nature Methods. 13 (4): 279. doi:10.1038/nmeth.3808. ISSN 1548-7091. PMID 27203785. S2CID 205424792.
^Anon (2013). "Job titles and duties at the University of Cambridge". University of Cambridge. Archived from the original on 3 July 2013.
^Anon (2015). "Dr Sarah Teichmann FMedSci". tcm.phy.cam.ac.uk. Cambridge. Archived from the original on 12 September 2015.
^Dhillon, Paraminder; Teichmann, Sarah A. (2019). "In conversation with Sarah Teichmann". The FEBS Journal. 286 (8): 1445–1450. doi:10.1111/febs.14806. ISSN 1742-464X. PMID 31012289.
^ abcdAnon (2015). "Sarah Teichmann: 40th FEBS Congress - The Biochemical Basis of Life - Berlin, Germany". Federation of European Biochemical Societies. Archived from the original on 20 February 2015.
^Teichmann, Sarah Amalia (1999). Genome evolution : analysing proteomes with new methods (PhD thesis). University of Cambridge. OCLC 894602472. EThOS uk.bl.ethos.624585.
^Luscombe, N. M.; Babu, M. M.; Yu, H; Snyder, M; Teichmann, S. A.; Gerstein, M (2004). "Genomic analysis of regulatory network dynamics reveals large topological changes". Nature. 431 (7006): 308–12. Bibcode:2004Natur.431..308L. doi:10.1038/nature02782. PMID 15372033. S2CID 4391278.
^Sarah A. Teichmann author profile page at the ACM Digital Library
^Carninci, P; Kasukawa, T; Katayama, S; Gough, J; Frith, M. C.; Maeda, N; Oyama, R; Ravasi, T; Lenhard, B; Wells, C; Kodzius, R; Shimokawa, K; Bajic, V. B.; Brenner, S. E.; Batalov, S; Forrest, A. R.; Zavolan, M; Davis, M. J.; Wilming, L. G.; Aidinis, V; Allen, J. E.; Ambesi-Impiombato, A; Apweiler, R; Aturaliya, R. N.; Bailey, T. L.; Bansal, M; Baxter, L; Beisel, K. W.; Bersano, T; et al. (2005). "The transcriptional landscape of the mammalian genome". Science. 309 (5740): 1559–63. Bibcode:2005Sci...309.1559F. doi:10.1126/science.1112014. PMID 16141072. S2CID 8712839.
^Drosophila 12 Genomes, Consortium; Clark, A. G.; Eisen, M. B.; Smith, D. R.; Bergman, C. M.; Oliver, B; Markow, T. A.; Kaufman, T. C.; Kellis, M; Gelbart, W; Iyer, V. N.; Pollard, D. A.; Sackton, T. B.; Larracuente, A. M.; Singh, N. D.; Abad, J. P.; Abt, D. N.; Adryan, B; Aguade, M; Akashi, H; Anderson, W. W.; Aquadro, C. F.; Ardell, D. H.; Arguello, R; Artieri, C. G.; Barbash, D. A.; Barker, D; Barsanti, P; Batterham, P; et al. (2007). "Evolution of genes and genomes on the Drosophila phylogeny". Nature. 450 (7167): 203–18. Bibcode:2007Natur.450..203C. doi:10.1038/nature06341. PMID 17994087.{{cite journal}}: CS1 maint: numeric names: authors list (link)
^Wilson, D; Charoensawan, V; Kummerfeld, S. K.; Teichmann, S. A. (2008). "DBD--taxonomically broad transcription factor predictions: New content and functionality". Nucleic Acids Research. 36 (Database issue): D88–92. doi:10.1093/nar/gkm964. PMC2238844. PMID 18073188.
^Levy, E. D.; Teichmann, S (2013). "Structural, Evolutionary, and Assembly Principles of Protein Oligomerization". Oligomerization in Health and Disease. Progress in Molecular Biology and Translational Science. Vol. 117. pp. 25–51. doi:10.1016/B978-0-12-386931-9.00002-7. ISBN 9780123869319. PMID 23663964.
^Perica, T; Kondo, Y; Tiwari, S. P.; McLaughlin, S. H.; Kemplen, K. R.; Zhang, X; Steward, A; Reuter, N; Clarke, J; Teichmann, S. A. (2014). "Evolution of oligomeric state through allosteric pathways that mimic ligand binding". Science. 346 (6216): 1254346. doi:10.1126/science.1254346. PMC4337988. PMID 25525255.
^"Teichmann group Research EMBL-EBI". European Bioinformatics Institute. 2013. Archived from the original on 2 April 2013.
^Anon (2015). "UK Government research grants awarded to Sarah Teichmann". Research Councils UK. Archived from the original on 3 March 2015.
^Teichmann, Sarah (2015). "Alumni from Sarah Teichmann's Group". European Bioinformatics Institute. Archived from the original on 20 February 2015.
^Charoensawan, Varodom (2011). Evolution and dynamics of transcription factors and gene expression patterns. ethos.bl.uk (PhD thesis). University of Cambridge. OCLC 890150091.
^De, Subhajyoti (2008). Human genome evolution : investigating protein divergence, polymorphisms and genomic neighbourhood. ethos.bl.uk (PhD thesis). University of Cambridge. OCLC 890154864.
^Han, Jay (2007). Structure, function and evolution of protein-protein interactions (PhD thesis). University of Cambridge.
^Kummerfeld, Sarah Kay (2006). Towards understanding the protein universe : genome-scale studies of evolution and gene regulation. ethos.bl.uk (PhD thesis). University of Cambridge.
^Levy, Emmanuel Doram (2008). Classification, evolution, and assembly of protein complexes. ethos.bl.uk (PhD thesis). University of Cambridge.
^Perica, Tina (2013). Evolutionary and structural dynamics of protein complexes (PhD thesis). University of Cambridge. OCLC 890148231.
^Su, Jing (2012). Computational prediction of regulatory elements (PhD thesis). University of Cambridge.
^Adryan, B; Teichmann, S. A. (2010). "The developmental expression dynamics of Drosophila melanogaster transcription factors". Genome Biology. 11 (4): R40. doi:10.1186/gb-2010-11-4-r40. PMC2884543. PMID 20384991.
^Gsponer, J; Futschik, M. E.; Teichmann, S. A.; Babu, M. M. (2008). "Tight regulation of unstructured proteins: From transcript synthesis to protein degradation". Science. 322 (5906): 1365–8. Bibcode:2008Sci...322.1365G. doi:10.1126/science.1163581. PMC2803065. PMID 19039133.
^Hebenstreit, D; Gu, M; Haider, S; Turner, D. J.; Liò, P; Teichmann, S. A. (2011). "EpiChIP: Gene-by-gene quantification of epigenetic modification levels". Nucleic Acids Research. 39 (5): e27. doi:10.1093/nar/gkq1226. PMC3061070. PMID 21131282.
^ abAnon (2012). "Honour and heirloom for Sarah Teichmann". Laboratory of Molecular Biology. Archived from the original on 3 March 2015.
^Anon (2015). "Women at Cambridge: Sarah Amalia Teichmann". University of Cambridge. Archived from the original on 20 February 2015.
^"Biophysical Society Names 2015 Award Recipients" (PDF). Biophysical Society. Archived from the original (PDF) on 4 October 2014. Retrieved 8 March 2015.
^Gaskell & Kostic (2015). "The Unstoppable Sarah Teichmann on Programing, Motherhood, and Protein Complex Assembly:The Female Scientist". Cell. Archived from the original on 2 April 2016. Retrieved 25 November 2015.
^Franklin-Wallis, Oliver (23 May 2020). "From pandemics to cancer: the science power list". The Times. ISSN 0140-0460. Retrieved 26 May 2020.
^"Sarah Teichmann". Royal Society. Retrieved 20 September 2020.
^"FEBS | EMBO Women in Science Award - FEBS". 26 August 2022. Retrieved 4 January 2024.
^Teichmann, Sarah; Teichmann, Virginia (1991). Cornelsen English Library - Fiction: 8. Schuljahr, Stufe 1 - Teenage Detectives: Textheft. Mit Aufgaben und Activities. Germany: Cornelsen Verlag. ISBN 978-3464053362.
^Anon. "The Honeycomb: Dr. Virginia Teichmann: Word Lover" (PDF). expat-karlsruhe.com. Retrieved 7 December 2015.