Inside Saskatoon's eastern city limits, Highway 5 connects with Highway 41 at the site of a small commercial area that, as of 2007, included the Sundown Drive-In, one of Canada's last operational drive-in movie theatres.^[2] At Km 2.9, Highway 41 heads north-east and crosses Llewellin Road, exiting Saskatoon's city limits. The Agra Road intersection is at Km 4.2. Continuing north-east, Highway 41 meets with Bettken Road at Km 9.8. The intersection with Highway 27 is at Aberdeen. Alvena can be accessed at Km 40.1. One Arrow 95-1C Indian reserve is north of the highway at Km 61.9. Travel continues north-east arriving at the Highway 22 intersection at Km 78.0. Highway 312 is just north of this intersection meeting with Highway 22. Travel west along Highway 312 will traverse the South Saskatchewan River via the Gabriel Bridge.^[3] Travel continues on Highway 41 due east. The town of Wakaw and Wakaw Lake Regional Park are accessed via Highway 2. At Km 95.0, the highway returns to its north-east direction. The village of Reynaud is to the east of this mile point. At Km 107.8, Highway 41 intersects with Highway 20. Yellow Creek is located at Km 117.8; travel on Highway 41 is due east at this juncture. In approximately 12 miles (19 km), the highway returns to its north-east direction. Meskanaw is located at Km 129.6. Travel along Highway 41 is now due east. There is a curve at Km 138.1 when Highway 41 meets with Highway 776 which continues the due east direction. Highway 41 travels in a north-east direction. At Km 148.5, Highway 41 intersects with Highway 368. Highway 3 and Highway 6, the CanAm Highway are travelling south and north as a concurrency when they intersect with Highway 41 south of the city of Melfort.^[1]

As of July 2010, several kilometres of Highway 41 were included in a large annexation of land undertaken by the city of Saskatoon.^[4][5]

The Fish Creek Historical Site commemorates Major General Frederick Middleton's camp. The actual Battle of Fish Creek occurred 1 mile (1.6 km) south-east of this camp. The Clarkboro Ferry crosses the South Saskatchewan River near the old ferry crossing which was named Clarke's Crossing. Clarke's Crossing was used by General Middleton's troops when travelling to the Fish Creek Battle en route from North Battleford. There is a marker on the Edenburg road which pays tribute to Clarke's Crossing Ferry service.^[6] The city of Melfort provides a campground at the highway junction of Highway 3, the CanAm, and Highway 41. The historical Melfort power house has been renovated for the Melfort and District Museum.^[7]

From west to east:^[8]

Highway 41A is a spur route of Highway 41. It runs from Highway 41 to Highway 3 along the western edge of Melfort and serves as part a business loop through Melfort. It is about 3.4 kilometres (2.1 mi) long.^[1]

• Transportation in Saskatchewan
• Roads in Saskatchewan

• Our pride and heritage: history of Yellow Creek and the surrounding school districts of Hazel Lake, Rhona Lake, Stoneless, Tarnopol, New Tarnopol, Yellow Creek. Yellow Creek, SK: Yellow Creek History Committee. 1982. ISBN 0-88925-316-1.

• Saskatchewan Road Map RV Itineraries