Billington's career began in Boston in the early 1970s, when he managed the New England Music City record store and edited the music magazine Pop Top. He was a member of the Boston Blues Society, which staged concerts by Son House, Mance Lipscomb, Johnny Shines and other first-generation bluesmen. In the mid-1970s he joined the staff of Rounder Records, where he first worked in the record label's sales, promotion and art departments.

In 1978, he and author Peter Guralnick edited live Boston Blues Society tapes to produce the Johnny Shines' album, Hey-Ba-Ba-Re Bop. He began producing for musicians in genres of music such as blues, Cajun, jazz and zydeco. His 1981 production of bluesman Clarence "Gatemouth" Brown won the first Grammy Award for Rounder Records. In the mid-1980s, he created the Modern New Orleans Masters Series for Rounder. Over the years, he has produced Charlie Rich, Solomon Burke, Johnny Adams, The Dirty Dozen Brass Band, Soul Rebels Brass Band, Irma Thomas, James Booker, Tangle Eye, Girl Authority among other artists on Rounder and other labels. His records have won a total of 3 Grammy® Awards and 11 Grammy® nominations.

As a harmonica player, Billington has recorded with Irma Thomas, Boozoo Chavis, Sleepy LaBeef, Johnette Downing, Theryl deClouet and others. He has toured with Nathan Williams & the Zydeco Cha Chas, a Louisiana-based zydeco band, appearing at the New Orleans Jazz and Heritage Festival, the Efes Pilsen Blues Festival (Istanbul) and the Montreal Jazz Festival. He played harmonica on the soundtrack to the Henry Fonda/Myrna Loy ABC-TV film, Summer Solstice, and on the PBS-TV series Zoom and Nova.

Billington's writing has appeared in Yankee, the Oxford American, Gambit and The Boston Globe. He has also written liner notes for many of his recordings. He has lectured at Harvard University, the New England Conservatory of Music, and Loyola University, as well as at several Grammy in the Schools events. As a graphic designer and art director, Billington created hundreds of album covers for Rounder and other labels.^[5]

Billington is employed as vice president of A&R for Rounder/Concord Records. He lives in New Orleans with his wife, the children's musician and author Johnette Downing, with whom he performs as the duo Johnette and Scott.

1982 edit

• Grammy Award (co-producer of Clarence "Gatemouth" Brown's Alright Again!)

1984 edit

• Communication Arts Magazine Award of Excellence

1985 edit

• Appointment as Colonel on the staff of Louisiana Governor Edwin W. Edwards

1987 edit

• Communication Arts Magazine Award of Excellence

1989 edit

• Nominated as Producer of the Year, Boston Music Awards

1990 edit

• Nominated as Producer of the Year, Boston Music Awards

1996 edit

• Offbeat Magazine (New Orleans) Best Producer Award (shared with Allen Toussaint)

2002 edit

• Keeping the Blues Alive Award for Producer, awarded by The Blues Foundation

2007 edit

• Sweet Soul Music Award, awarded by the Porretta Soul Festival, Porretta Terme, Italy

• Grammy Award (producer of Irma Thomas's After the Rain)

2010 edit

• Grammy nomination (co-producer of Woody Guthrie's My Dusty Road collection)

2011 edit

• Offbeat (New Orleans) Lifetime Achievement Award

2017 edit

• Grammy Award (Producer of Bobby Rush's Porcupine Meat)

• Official website
• Ankeny, Jason. Biography of Scott Billington at AllMusic. Retrieved 2012-04-20.