Senedjemib Mehi held many titles, all recorded in his tomb, showing that he made a successful career:^[2]

• "Pillar of the knmt-folk"
• "Favorite of the king" and "favorite of the king wherever he is"
• "Overseer of the two workshops"
• "Overseer of the two armories"
• "Overseer of the two houses of gold"
• "Overseer of (all) royal regalia"
• "Overseer of scribes of royal records"
• "Overseer of royal linen"
• "Overseer of the two granaries"
• "Overseer of all works of the king"
• "Hereditary prince"
• "Royal master builder in both houses" (i.e. in Upper and Lower Egypt)
• "True count"
• "Master of secrets of all commands of the king"
• "Royal chamberlain"
• "Sole friend" (i.e. of the king)
• "Chief justice and vizier”

Senedjemib Mehi was the son of Senedjemib Inti and Tjefi. Mehi was married to Khentkaus, who was a King's daughter. She could be a daughter of Unas or possibly of Djedkare Isesi. They had at least three children:^[3]

• Senedjemib, named after his grandfather
• Mehi, named after his father
• Khentkaus, named after her mother

Senedjemib Mehi was buried in tomb G2378 in Giza West Field immediately next to the tomb of his father.

•  
  Mastaba of Senedjemib Inti (father), the tomb of Senedjemib Mehi (son) is immediately to the left.
•  
  wooden statue of Senedjemib Mehi, Museum of Fine Arts, Boston