Sergio Santos may refer to:

• Sergio Santos (baseball) (born 1983), American baseball player
• Sérgio Santos (volleyball) (born 1975), also known as Serginho or Escadinha, Brazilian volleyball player
• Sergio Santos (footballer, born 1994), Brazilian football forward for FC Cincinnati
• Sérgio Santos (footballer, born 1998), Portuguese football forward for Portimonense
• Sergio Santos (footballer, born 2001), Spanish football right-back for Real Madrid