Sesam, SESAM or SeSaM may refer to:

• SESAM (database), a relational database developed by Fujitsu Siemens
• SESAM (FEM), a structural analysis software
• Sesam (search engine), a Scandinavian internet search engine
• SeSaM-Biotech GmbH, a biotechnology company focusing on protein engineering
• Semiconductor saturable-absorber mirror, a component used in some lasers
• Sequence saturation mutagenesis (SeSaM), a molecular biology method for diversity creation by random mutagenesis