Severn Freewheelers works for hospitals in Gloucestershire, Herefordshire, Worcestershire and north Wiltshire, including Swindon.

Operations extend into southern Birmingham and Coventry. Major hospitals served include Gloucester Royal, Cheltenham General, Hereford County, Worcester Royal, Redditch Alexandra and Great Western, Swindon, with many smaller hospitals also served including Tewkesbury, Moreton-in-Marsh, Cinderford, Stroud, Dursley, Cirencester, Ross-on-Wye, Leominster, Bromyard, Ledbury, Kidderminster, Bromsgrove, Malvern, Tenbury Wells, Evesham, Pershore, Chippenham and Savernake.

Operating between 7 pm and 7 am on weekdays and 24 hours at weekends and public holidays, the charity provides a service enabling hospitals to avoid the need to use taxis or commercial couriers, saving the NHS an estimated £150,000 each year across the area.^{[citation needed]}

By December 2019, the charity had covered over 1,700,000 miles, had responded to more than 46,000 calls,^[4] and was receiving over 500 calls each month. Items carried include samples for pathological or micro-biological analysis, blood and blood products for transfusion, patient notes, drugs, scans and medical equipment. Recent developments include the collection of human breast milk from donors’ homes and its transport to human milk banks at Oxford, Bristol and Birmingham.

During the coronavirus-19 crisis the charity responded by temporarily extending its service to operate 24/7. In addition, some 80 volunteers were recruited from the general public to make home deliveries of medications from general hospitals in Hereford and Gloucestershire. Nearly 3,000 deliveries had been made as of September 2020.

In 2011, the charity held its first Prescott Bike Festival at the Prescott Speed Hill Climb circuit near Bishop's Cleeve in Gloucestershire, which attracted 5,000 visitors.^[5] This has since become an annual event.

It also mounts displays at local shows such as the Three Counties Show, the Cotswold Show, the Emergency Services Show,^[6] and local music festivals, and attends motorcycle safety events such as BikeSafe. Several motorcycling celebrities including racers Carl Fogarty and Jamie Whitham have offered to help support the charity in raising funds to support its work.^[7]

A new-look website was launched in March 2024.

• Official website  
• "Severn Freewheelers, registered charity no. 1120999". Charity Commission for England and Wales.