Shamsuddin Ahmed may refer to:

• Shamsuddin Ahmad Shah (1419–1436), Sultan of Bengal
• Shamsuddin Ahmed (surgeon) (1920–1971), East Pakistan medical doctor killed in the Bangladesh Liberation war
• Shamsuddin Ahmed Ishaq (1941–2005), Bangladeshi poet and politician
• Samsuddin Ahmed (1945–2020), Bangladeshi former MP
• Shamsuddin Ahmed (Naogaon-5 MP), Bangladeshi politician
• Shamsuddin Ahmed (Mymensingh-6 MP) (died 2020), Bangladeshi engineer and politician
• Shamsuddin Ahmed, Bangladeshi former MP
• Shamsuddin Ahmad Chowdhury, Bangladeshi physician and politician