The tracks through the site were opened in 1992; however, the tram stop did not open until 31 March 2003. The bus part of the interchange opened on 29 January 2006.^[1] Construction had initially started on the bus station in 1998 and it was planned to have been completed and fully operational by 2000, but several disputes over the ownership of the site along with two public inquiries over the course of five years resulted in the construction work on the station being halted until 2003.^[2]

The Shudehill stop is in Zone 1, forming part of the First City Crossing. Trams run through Shudehill to Bury, Altrincham, Manchester Airport, Piccadilly and Victoria.^[3] Services run every twelve minutes on each route at most operating times.

The bus station, designed by Jefferson Sheard Architects, replaced the former Cannon Street bus station, under the Manchester Arndale; since the redevelopment of Manchester city centre, the latter has disappeared along with Cannon Street itself.^[4] The Bus station is now under the control of TfGM through the Bee Network (as of 2024).

Bus services are operated by the Bee Network: Go North West and Stagecoach Manchester.^[5]

There are frequent buses to destinations in the north and the west of Greater Manchester, including Bolton, Bury, Eccles, Middleton, Rochdale, Salford and the Trafford Centre. The bus station is also served by night buses because of its location near the Printworks and Free bus around the city Route 2.

Coach services are operated by Flixbus and Megabus.

In April 2009, the Manchester Megabus stop moved from the Chorlton Street coach station to Shudehill Interchange.

Flixbus began intercity services to Manchester Shudehill from London in 2020.

• Tram times and station information for Shudehill Interchange from Manchester Metrolink
• City centre Metrolink map