Born in Bergamo, in northern Italy, to middle-class parents, Moro grew up in the borough of Valtesse and was actively encouraged by his father in his passion for the mountains. His father was an accomplished climber and cyclist and also fostered a lively and international environment around him. He started climbing on the Presolana and other massifs of the Bergamasque Alps at the age of 13. In 2003, at 35, he completed his university studies and graduated cum laude.

Moro began his climbing activity on the Grigne near his home city. His father was his first mentor, and later Alberto Cosonni and Bruno Tassi. At that time he was primarily involved in rock climbing, an activity he has never given up. In 1992 he participated in his first Himalayan expedition, to Mount Everest. One year later Moro climbed Aconcagua. He made expeditions to other mountains in the 1990s, including Cerro Mirador and Makalu in 1993; Shishapangma and Lhotse in 1994, Kangchenjunga in 1995. In 1996 Moro climbed the west wall of Fitz Roy (3,341 m (10,961 ft) in Patagonia) in 25 hours from the base to the summit and back to the base. In the same year, he climbed Shishapangma South (8,008 m [26,273 ft]) without oxygen in 27 hours using skis in the descent from 7,100 m (23,300 ft). In 1997 he summited Lhotse. In Winter of 1997 he attempted the South face of Annapurna. During this attempt, his climbing companions Anatoli Boukreev and Dimitri Sobolev died in an avalanche. He tried Everest again in 1998; summited four peaks Pik Lenin (7,134 m (23,406 ft)), Peak Korzhenevskaya (7,105 m [23,310 ft]), Ismoil Somoni Peak (7,495 m (24,590 ft), formerly known as Pik Kommunizma), Pik Khan Tengri (7,010 m [23,000 ft]) with young Kazakhstan guide Denis Urubko; then summited Everest with him in 2000^[13] and Marble Wall in winter 2001.

In 2002 he summited three peaks: Mount Vinson, Cho Oyu^[14] and Everest;^[15] summited three peaks: Broad Peak,^[16] Elbrus and Kilimanjaro in 2003, summited Baruntse along a new route and tried Shishapangma and Annapurna in 2004; Batura and Batokshi peaks in 2005, Broad Peak in winter 2006 and 2007. In 2005 he achieved the first winter summit of Shishapangma, with Piotr Morawski.^[1] In 2006 he completed a solo south–north traverse of Everest descending from the top in five hours.^[17]

In 2008 he made (with Hervè Barmasse) the first ascent of Beka Brakai Chhok (6,950 m (22,800 ft) Karakorum). The climbing was in pure alpine style and in 43 hours.^[18]

In January 2009 Moro made the first winter ascent of Makalu with Denis Urubko,^[4] and in February 2011 the first winter ascent of Gasherbrum II with Denis Urubko and Cory Richards.^[6] In April 2013, Moro, while climbing with Ueli Steck who was preparing for a traverse next spring of Everest and Lhotse, got into an altercation with disgruntled sherpas that according to The Guardian: "... went viral and Steck, wholly blameless in the affair, became severely depressed and disheartened".^[19] In February 2016, Moro completed the first winter ascent of Nanga Parbat with Alex Txikon and Ali Sadpara.^[20] In February 2018, he completed the first winter ascent of Peak Pobeda, Sakha along with fellow Italian mountaineer Tamara Lunger.^[21]

In May 2001 he tried to traverse Everest–Lhotse: during an attempt on the wall of Lhotse at 8000 metres he abandoned the climb to search, rescue, and save English alpinist Tom Moores. Moro was a recipient of the Fair Play Pierre de Coubertin trophy from UNESCO,^[22] the Civilian Gold Medal from Italian president Carlo Azeglio Ciampi^[23] and the David A. Sowles Memorial Award from the American Alpine Club.^[24] Tom Moores recalls his meeting with Moro this way:

On the way down we met Simone who had unfortunately failed to get to the summit because of the energy he had used rescuing me. I felt and still feel very guilty, but Simone who is a very humble man shrugged his shoulders and said, "It is no problem. In the future, I can still climb and you can still climb and that's more important than any summit." His sentiment is a lesson to us all, I believe it’s a perfect example of the true climbing spirit. I will never be able to thank him enough for what he did for me, he is an amazing man and a real hero.

— Tom Moores, 2001^[25]

In 2009, he bought a helicopter with his own money to carry out search and rescue operations in the Nepalese Himalayas for Nepalese people.^[11][26] He has piloted the helicopter several times to rescue alpinists, sherpas, trekkers, and people in remote areas.^[11][27]

In 2003, Moro projected and financed a school for 396 Sherpa children in the Nepalese village of Syadul. The objective of the project, carried with an Italian foundation, was to prevent early school-leaving in the area.^[28][29] The school was opened in 2005. It is located in a village a thousand meters above sea level and three hours from the nearest road.^[30]

Near the Nanga Parbat base camp, he financed, built, and donated to the Pakistani district of Gilgit Baltistan a small masonry building for local shepherds and a small hospital in the village of Ser.^[31]

• 1996, 2005^[1] – Shishapangma, first winter ascent (2005)
• 1997 – Lhotse
• 2002 – Cho Oyu^[14]
• 2003 – Broad Peak^[16]
• 2009 – Makalu, first winter ascent^[4]
• 2000,^[13] 2002,^[15] 2006,^[17] 2010^[32] – Mount Everest
• 2011 – Gasherbrum II, first winter ascent^[6]
• 2016 – Nanga Parbat, first winter ascent ^[7][8]

• Moro, Simone (2003). Cometa sull'Annapurna (in Italian). Corbaccio. ISBN 9788879725903.
• Moro, Simone (2008). 8000 metri di vita (in Italian). Grafica e Arte. ISBN 9788872012727.
• Moro, Simone (2016). Nanga (in Italian). Rizzoli. ISBN 9788817090230.

• Official website
• Interview on planetmountain.com (in Italian)