A edit

• Alan Simons (born 1968), Welsh goalkeeper
• Alexandra Simons de Ridder (born 1963), German equestrian
• Algie Martin Simons (1870–1950), American socialist journalist, newspaper editor and political activist
• Andra Simons, Bermudian writer
• Ann Simons (born 1980), Belgian judoka
• Arthur D. Simons (1918–1979), U.S. Army Special Forces officer

B edit

• Barbara Simons (born 1941), American computer scientist
• Benjamin Simons, British theoretical physicist
• Billy Simons (born 1983), American singer

C edit

• Carlos Simons (born 1954), Turks and Caicos Islands lawyer
• Charles Simons (footballer) (1906–1979), Belgian footballer
• Charles Casper Simons (1876–1964), American judge
• Charles Earl Simons, Jr. (1916–1999), American judge
• Charles-Mathias Simons (1802–1874), Luxembourg politician
• Claude Simons, Jr. (1914–1975), American college sports coach
• Claude Simons, Sr. (1887–1943), American college sports coach

D edit

• Danielle Simons (born 1969), American psychologist and cognitive scientist
• Dave Simons (1954–2009), American comic book artist
• David G. Simons (1922–2010), American physician and Airforce pilot
• Dot Simons (1912–1996), New Zealand sportswoman, sports journalist and writer
• Doug Simons (born 1966), American baseball pitcher

E edit

• Ed Simons (conductor) (1917–2018), American violinist and conductor
• Elwyn L. Simons (1930–2016), American paleontologist
• Eric Simons (born 1962), South African cricketer
• Eva Simons (born 1984), Dutch singer-songwriter

F edit

• F. Estelle R. Simons (born 1945), Canadian scientist

G edit

• Geoff Simons (1939–2011), British freelance writer

H edit

• Heintje Simons (born 1955), Dutch singer and actor
• Hellmuth Simons (1893–1969), German bacteriologist
• Henry Calvert Simons (1899–1948), American economist
• Howard Simons (1929–1989), American journalist
• Hywel Simons (born 1970), Welsh actor

J edit

• Jack Simons (1882–1948), Australian businessman and politician
• James Harris Simons (born 1938), American mathematician and hedge fund-manager
• Jan Simons (1925–2006), Canadian baritone
• Jennifer Simons (born 1953), Surinamese politician
• Jesse Simons (1917–2006), American labor arbitrator
• Jim Simons (golfer) (1950–2005), American professional golfer
• Joe Simons (born 1947), Dutch ice hockey player
• Joseph H. Simons (1897–1983), American chemist
• Johan Simons (born 1946), Dutch theatre director
• John Simons, British radio executive
• John Simons (chemist) (born 1934), British physical chemist
• Jonathan Simons (born 1958), American physician and oncologist
• Jozef Simons (1888–1948), Flemish writer and poet
• Jud Simons (1904–1943), Dutch gymnast

K edit

• Keneth Alden Simons (1913–2004), American electrical engineer
• Kip Simons, American gymnast

L edit

• Lao Genevra Simons (1870–1949), American mathematician and writer
• Lesley Simons

M edit

• Margaret Simons (born 1960), Australian journalist and writer
• Marlise Simons, Dutch journalist for the New York Times
• Marylin Simons, (born 1959), Surinamese writer
• Matt Simons, American singer-songwriter and musician
• May Wood Simons (1876–1948), American writer, teacher and socialist
• Mel Simons (1900–1974), American baseball player
• Menno Simons (1496–1561), Dutch Anabaptist
• Moisés Simons (1889–1945), Cuban composer

N edit

• Nancy Simons (born 1938), American swimmer
• Nicholas Simons, Canadian politician
• Netty Simons (1913–1994), American pianist, music editor, music educator and composer
• Nina Simons (born 1957), American businesswoman

P edit

• Paul E. Simons, American diplomat
• Paullina Simons (born 1953), Russian author
• Perla Simons (born 1963), Honduran politician
• Peter Simons (academic) (born 1950), British philosopher
• Peter Simons (businessman) (born 1964), Canadian businessman

R edit

• Rachel Simons (1914–2004), South African communist and trade unionist
• Raf Simons (born 1968), Belgian fashion designer
• Regillio Simons (born 1973), Dutch footballer
• Renee Simons (born 1972), Canadian curler
• Richard D. Simons (1927–2022), New York State judge
• Rita Simons (born 1977), English actress, singer and model
• Robert Simons (cricketer) (1922–2011), English cricketer
• Robert Simons (economist) American economist
• Ronald C. Simons (born 1935), American psychiatrist and anthropologist
• Ronald L. Simons (born 1946), American criminologist and sociologist
• Rosearik Rikki Simons (born 1970), American voice actor and writer

S edit

• Samuel Simons (1792–1847), American politician from Connecticut
• Seymour Simons (1896–1949), American pianist, composer, orchestra leader, and radio producer
• Shirley Simons (1897–1963), American architect
• Simeon Simons (1759–1853), Native American bodyguard of George Washington
• Simone Simons (born 1985), Dutch mezzo-soprano
• Sylvana Simons (born 1971), Dutch television presenter and politician

T edit

• Thomas Simons (born 2004), British Youtuber and Twitch streamer (known online as TommyInnit)
• Timmy Simons (born 1976), Belgian footballer

W edit

• Walter Simons (1861–1937), German lawyer and politician
• William Simons (1940–2019), Welsh actor

X edit

• Xavi Simons (born 2003), Dutch footballer

• La Maison Simons
• Fitzsimmons
• Simmonds
• Simmons (surname), Simmons (disambiguation)
• Simon (surname), Simon (disambiguation)
• Simonds (disambiguation)
• Simone (disambiguation)
• Symonds
• Symons