Sirona may refer to

• Sirona (goddess), Celtic deity
• Dentsply Sirona, company created in the 2016 merger of Sirona Dental Systems with Dentsply International
• Sirona Care & Health, British community interest company
• 116 Sirona, main-belt asteroid
• Sirona Ryan, fictional character in the 2023 video game Hogwarts Legacy
• USS Sirona (1945-1966), American Navy ship