Sodium salicylate is a sodium salt of salicylic acid. It can be prepared from sodium phenolate and carbon dioxide under higher temperature and pressure. Historically, it has been synthesized by refluxing methyl salicylate (wintergreen oil) with an excess of sodium hydroxide.[4]
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Preferred IUPAC name
Sodium 2-hydroxybenzoate | |
Other names
Salsonin, Monosodium salicylate, Sodium o-hydroxybenzoate, Salicylic acid sodium salt, Monosodium 2-hydroxybenzoate, Diuratin
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ECHA InfoCard | 100.000.181 |
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Properties | |
C7H5NaO3 | |
Molar mass | 160.104 g/mol |
Appearance | White crystals |
Melting point | 200 °C (392 °F; 473 K) |
25.08 g/100 g (-1.5 °C) 107.9 g/100 g (15 °C) 124.6 g/100 g (25 °C) 141.8 g/100 g (78.5 °C) 179 g/100 g (114 °C)[1] | |
Solubility | Soluble in glycerol, 1,4-Dioxane, alcohol[1] |
Solubility in methanol | 26.28 g/100 g (15 °C) 34.73 g/100 g (67.2 °C)[1] |
Pharmacology | |
N02BA04 (WHO) | |
Hazards | |
Occupational safety and health (OHS/OSH): | |
Main hazards
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Harmful |
Eye hazards
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Irritant |
GHS labelling:[3] | |
Warning | |
H314, H331, H400 | |
P210, P261, P273, P280, P305+P351+P338, P310 | |
NFPA 704 (fire diamond) | |
250 °C (482 °F; 523 K) | |
Lethal dose or concentration (LD, LC): | |
LD50 (median dose)
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930 mg/kg (rats, oral)[2] |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references
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Sodium salicylate is of the salicylate family.
It is used in medicine as an analgesic and antipyretic. Sodium salicylate also acts as non-steroidal anti-inflammatory drug (NSAID), and induces apoptosis in cancer cells [5][6][7] and also necrosis.[8] It is also a potential replacement for aspirin for people sensitive to it. It may also be used as a phosphor for the detection of vacuum ultraviolet radiation and electrons.[9]