The South Carolina Lowcountry National Wildlife Refuge Complex is an administrative organization that manages U.S. Fish and Wildlife Service wildlife refuges in eastern South Carolina. The complex includes:

• Cape Romain National Wildlife Refuge
• Waccamaw National Wildlife Refuge
• Mackay Island National Wildlife Refuge
• Santee National Wildlife Refuge
• Ernest F. Hollings ACE Basin National Wildlife Refuge

The complex headquarters and visitor center is in the Alligator River refuge headquarters on Roanoke Island.^[1]