Southwest Airways, a defunct post-World War II domestic United States regional airline
Air Southwest, a British airline operating from 2003 to 2010
Former railroad routesedit
A Chicago-Los Angeles train operated by Amtrak, and now known as the Southwest Chief
Southwest Limited (MILW) formerly operated by the Chicago, Milwaukee, St. Paul and Pacific Railroad ("the Milwaukee Road") between Chicago/Milwaukee and Kansas City
Southwestern Limited (IC train), an Illinois Central train, from Meridian, Mississippi to Shreveport, Louisiana, discontinued in 1967