Space Case may refer to the following:

• Space Case (1992 film), starring Bridget Hoffman
• Space Case (2001 film), starring Christopher Lloyd, produced by Weston Woods Studios
• "Space Case", an episode of Big Bad Beetleborgs
• "Space Case", an episode of Reading Rainbow
• "Space Case", an episode of Slimer! and the Real Ghostbusters
• Space Case (Transformers), a character in Transformers, one of the Cyberjets
• Space Case, a 2014 book by Stuart Gibbs, from the Moon Base Alpha series