Spiers is an English surname. Notable people with the surname include:

• Alexander Spiers (1807–1869), English lexicographer
• Bob Spiers (1945–2008), British television director
• Carson Spiers (born 1997), American baseball player
• Cyril Spiers (1902–1967), former English professional footballer and manager
• Dick Spiers (1937–2000), English footballer
• Edward Louis Spiers, later Edward Spears (1886–1974), British Army officer and politician
• Elizabeth Spiers (born 1976), the founding editor of gossip blog Gawker.com and the Wall Street gossip site dealbreaker.com
• Felix William Spiers (1832–1911), founder of Spiers & Pond, restaurateurs
• Hetty Spiers (1881–1973), theatre and film costumier and screenwriter
• John Spiers (born 1975), English squeezebox player, founder member of folk duo Spiers and Boden and Bellowhead
• Reg Spiers (born 1941), Australian athlete known for traveling in a wooden box from England to Australia
• Richard Phené Spiers (1838–1916), English architect and author
• Ronald I. Spiers (1925–2021), former American ambassador-diplomat and member of Diplomats and Military Commanders for Change
• Sarah Spiers, victim of the Claremont serial killings