The hospital was founded in 1884^[1] by the Protestant Episcopal church with large financial contributions from Horatio Hathaway, a church leader who was one of the founders of Berkshire Hathaway.^[2]

In 1996 St. Luke's merged with Charlton Memorial^[3] in Fall River and Tobey Hospital^[4] in Wareham to form the Southcoast Health System.

In 2006, St. Luke's began building a new Emergency Department. Inside there are nineteen new private treatment bays. In 2008, The In-House Patient Pharmacy Department installed a Drug dispensing system throughout the floors called Pyxis Connect. While its operations continue in 2009 as the upgrade to the OR Rooms and Endoscopy Departments received new machines per room.

St. Luke's has 293 beds in service and offers extensive in-patient medical and surgical services,^[5] with particular expertise in neurosurgery, cardiology, pediatric care, orthopedics, and general surgery. The hospitalist program delivers cutting-edge medical care precisely when patients require it, boasting specialized proficiency in neurosurgery, cardiology, pediatric care, orthopedics, and general surgery. Leveraging advanced technology, we offer patients comprehensive access to a wide array of diagnostic testing and rehabilitation services, conveniently available both on-site and at satellite locations.

St. Luke’s Emergency Department^[6] stands as one of Massachusetts' most bustling, delivering top-tier emergency services to nearby communities. Our New Bedford emergency facilities uphold the highest standards of care, ensuring patients receive exceptional treatment within a safe and welcoming setting. Additionally, we provide specialized pediatric services in collaboration with esteemed pediatricians from Boston Children’s Hospital, extending coverage to both the emergency room and pediatric unit.

• Southcoast Health System

41°37′35″N 70°56′17″W / 41.6265°N 70.9380°W / 41.6265; -70.9380