const is 7×24×60×60 seconds, the number of seconds in a week.
Interpretation of std Kt/VEdit
Standardized Kt/V can be interpreted as a concentration normalized by the mass generation per unit volume of body water.
Equation 7 can be written in the following way:
If one takes the inverse of Equation 8 it can be observed that the inverse of std Kt/V is proportional to the concentration of urea (in the body) divided by the production of urea per time per unit volume of body water.
Comparison to Kt/VEdit
Kt/V and standardized Kt/V are not the same. Kt/V is a ratio of the pre- and post-dialysis urea concentrations. Standardized Kt/V is an equivalent clearance defined by the initial urea concentration (compare equation 8 and equation 10).
Kt/V is defined as (see article on Kt/V for derivation):
Standardized Kt/V only models the clearance of urea and thus implicitly assumes the clearance of urea is comparable to other toxins. It ignores molecules that (relative to urea) have diffusion-limited transport - so called middle molecules.
The Standardized Kt/V is based on body water volume (V). The Glomerular filtration rate, an estimate of normal kidney function, is usually normalized to body surface area (S). S and V differ markedly between small vs. large people and between men and women. A man and a woman of the same S will have similar levels of GFR, but their values for V may differ by 15-20%. Because standardized Kt/V incorporates residual renal function into the calculations, it makes the assumption that kidney function should scale by V. This may disadvantage women and smaller patients of either sex, in whom V is decreased to a greater extent than S.
Calculating stdKt/V from treatment Kt/V and number of sessions per weekEdit
The various ways of computing standardized Kt/V by Gotch, Leypoldt, and the FHN trial network  are all a bit different, as assumptions differ on equal spacing of treatments, use of a fixed or variable volume model, and whether or not urea rebound is taken into effect. One equation, proposed by Leypoldt and modified by Depner that is cited in the KDOQI 2006 Hemodialysis Adequacy Guidelines and which is the basis for a web calculator for stdKt/V is as follows:
where stdKt/V is the standardized Kt/V spKt/V is the single-pool Kt/V, computed as described in Kt/V section using a simplified equation or ideally, using urea modeling, and eKt/V is the equilibrated Kt/V, computed from the single-pool Kt/V (spKt/V) and session length (t) using, for example, the Tattersall equation:
where t is session duration in minutes, and C is a time constant, which is specific for type of access and type solute being removed. For urea, C should be 35 minutes for arterial access and 22 min for a venous access.
The regular "rate equation"  also can be used to determine equilibrated Kt/V from the spKt/V, as long as session length is 120 min or longer.
Plot showing std Kt/V depending on regular Kt/V for different treatment regimensEdit
Plot relating standardized Kt/V, Kt/V and treatment frequency per week.
One can create a plot to relate the three grouping (standardized Kt/V, Kt/V, treatment frequency per week), sufficient to define a dialysis schedule. The equations are strongly dependent on session length; the numbers will change substantially between two sessions given at the same schedule, but with different session lengths.
For the present plot, a session length of 0.4 Kt/V units per hour was assumed, with a minimum dialysis session length of 2.0 hours.
^ abGotch FA (1998). "The current place of urea kinetic modelling with respect to different dialysis modalities". Nephrol Dial Transplant. 13 Suppl 6 (90006): 10–4. doi:10.1093/ndt/13.suppl_6.10. PMID9719197.
^Tattersall JE, DeTakats D, Chamney P, Greenwood RN, Farrington K (December 1996). "The post-hemodialysis rebound: predicting and quantifying its effect on Kt/V". Kidney Int. 50 (6): 2094–102. doi:10.1038/ki.1996.534. PMID8943495.
^Daugirdas JT, Greene T, Depner TA, et al. (January 2004). "Factors that affect postdialysis rebound in serum urea concentration, including the rate of dialysis: results from the HEMO Study". J Am Soc Nephrol. 15 (1): 194–203. doi:10.1097/01.ASN.0000103871.20736.0C. PMID14694173.