Elledge was born in Paris, Illinois in 1956.[2] He also grew in up, graduating from Paris High School in 1974. He has been interested in chemistry since childhood, thanks to a chemistry set his grandmother gave him.[5]
Over the next decade, he continued the search for genes and proteins involved in the DNA damage response pathway in yeasts and humans. Examples include DUN1,[19] MEC1, and TEL1 in yeasts,[20] (respective human homologs are CHEK2, ATR, and ATM) and CHEK1[21] and CHEK2[22] in humans.
Elledge's group also discovered the F-box protein structural motif, and found that it recognizes specific protein sequences and tags the proteins with ubiquitin for degradation.[26] He correctly predicted the central role of F-Box in protein degradation due to the large number of proteins having this motif.[27]
In 2015, Elledge's group developed VirScan, a platform that detects viral infection in patients from a small amount of blood.[28][29][30]
In recent years, Elledge has continued to expand his research area. For instance, his group reported a computational model that predicted the likelihood of regions on the chromosome to be abnormally amplified.[31][32]
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^Nadis, Steve. "A Drop of Blood, a History of Viruses". Discover. Archived from the original on December 12, 2016. Retrieved December 16, 2016.
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^Rogers, Kara (August 3, 2022). "Stephen J. Elledge". Encyclopædia Britannica. Retrieved March 23, 2023.{{cite web}}: CS1 maint: date and year (link)
^Azvolinsky, Anna (September 30, 2017). "Damage Patroller". The Scientist. No. October 2017. Archived from the original on July 26, 2020. Retrieved July 26, 2020.
^Peterson, Doug (November 1, 2013). "A Molecular Pathfinder". College of Liberal Arts & Sciences, University of Illinois Urbana-Champaign. Archived from the original on August 9, 2022. Retrieved August 9, 2022.
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^Elledge, Stephen J. (2015). "Accidents and Damage Control". Cell. 162 (6): 1196–1200. doi:10.1016/j.cell.2015.08.042. PMID 26359977.
^Elledge, S. J.; Davis, R. W. (1987). "Identification and isolation of the gene encoding the small subunit of ribonucleotide reductase from Saccharomyces cerevisiae: DNA damage-inducible gene required for mitotic viability". Molecular and Cellular Biology. 7 (8): 2783–2793. doi:10.1128/mcb.7.8.2783-2793.1987. PMC367895. PMID 3313004.
^"RNR2 ribonucleotide-diphosphate reductase subunit RNR2 [ Saccharomyces cerevisiae S288C ]". National Center for Biotechnology Information. March 10, 2023. Archived from the original on March 29, 2023. Retrieved March 29, 2023.
^Zhou, Zheng; Elledge, Stephen J. (1993). "DUN1 encodes a protein kinase that controls the DNA damage response in yeast". Cell. 75 (6): 1119–1127. doi:10.1016/0092-8674(93)90321-g. PMID 8261511. S2CID 6606697. Retrieved April 3, 2023.
^Sanchez, Yolanda; Desany, Brian A.; Jones, William J.; Liu, Qinghua; Wang, Bin; Elledge, Stephen J. (1996). "Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways". Science. 271 (5247): 357–360. Bibcode:1996Sci...271..357S. doi:10.1126/science.271.5247.357. PMID 8553072. S2CID 21223989. Retrieved April 3, 2023.
^Sanchez, Yolanda; Wong, Calvin; Thoma, Richard S.; Richman, Ron; Wu, Zhiqi; Piwnica-Worms, Helen; Elledge, Stephen J. (1997). "Conservation of the Chk1 Checkpoint Pathway in Mammals: Linkage of DNA Damage to Cdk Regulation Through Cdc25". Science. 277 (5331): 1497–1501. doi:10.1126/science.277.5331.1497. PMID 9278511. Retrieved April 3, 2023.
^Matsuoka, Shuhei; Huang, Mingxia; Elledge, Stephen J. (1998). "Linkage of ATM to Cell Cycle Regulation by the Chk2 Protein Kinase". Science. 282 (5395): 1893–1897. Bibcode:1998Sci...282.1893M. doi:10.1126/science.282.5395.1893. PMID 9836640. Retrieved April 3, 2023.
^Harper, J. Wade; Adami, Guy R.; Wei, Nan; Keyomarsi, Khandan; Elledge, Stephen J. (1993). "The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases" (PDF). Cell. 75 (4): 805–816. doi:10.1016/0092-8674(93)90499-g. PMID 8242751. S2CID 13614794. Archived from the original (PDF) on April 1, 2023. Retrieved April 1, 2023.
^Durfee, Tim; Becherer, Kathleen; Chen, Phang-Lang; Yeh, Shiou-Hwei; Yang, Yanzhu; Kilburn, April E.; Lee, Wen-Hwa; Elledge, Stephen J. (1993). "The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit" (PDF). Genes & Development. 7 (9): 555–569. doi:10.1101/gad.7.4.555. PMID 8384581. S2CID 23631016. Archived from the original (PDF) on April 1, 2023. Retrieved April 1, 2023.
^Elledge, S.J.; Spottswood, M.R. (1991). "A new human p34 protein kinase, CDK2, identified by complementation of a cdc28 mutation in Saccharomyces cerevisiae, is a homolog of Xenopus Eg1". EMBO Journal. 10 (9): 2653–2659. doi:10.1002/j.1460-2075.1991.tb07808.x. PMC452966. PMID 1714386.
^Bai, Chang; Sen, Partha; Hofmann, Kay; Ma, Lei; Goebl, Mark; Harper, J. Wade; Elledge, Stephen J. (1996). "SKP1 Connects Cell Cycle Regulators to the Ubiquitin Proteolysis Machinery through a Novel Motif, the F-Box". Cell. 86 (2): 263–274. doi:10.1016/s0092-8674(00)80098-7. PMID 8706131.
^Kipreos, Edward T.; Pagano, Michele (2000). "The F-box protein family". Genome Biology. 1 (5): reviews3002.1. doi:10.1186/gb-2000-1-5-reviews3002. PMC138887. PMID 11178263.
^Xu, George J.; Kula, Tomasz; Xu, Qikai; Li, Mamie Z.; Vernon, Suzanne D.; Ndung’u, Thumbi; Ruxrungtham, Kiat; Sanchez, Jorge; Brander, Christian; Chung, Raymond T.; O’Connor, Kevin C.; Walker, Bruce; Larman, H. Benjamin; Elledge, Stephen J. (2015). "Comprehensive serological profiling of human populations using a synthetic human virome". Science. 348 (6299): aaa0698. doi:10.1126/science.aaa0698. PMC4844011. PMID 26045439.
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^Davoli, Teresa; Xu, Andrew Wei; Mengwasser, Kristen E.; Sack, Laura M.; Yoon, John C.; Park, Peter J.; Elledge, Stephen J. (2013). "Cumulative haploinsufficiency and triplosensitivity drive aneuploidy patterns and shape the cancer genome". Cell. 155 (4): 948–962. doi:10.1016/j.cell.2013.10.011. PMC3891052. PMID 24183448.
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