Strongyle (Greek: Στρογγύλη Stroŋgýlē) may refer to:

• Strongyle (worm), or Strongylidae, a family of nematode worms
• Santorini, once known as Strongýlē, a Greek island in the Aegian Sea
• Stromboli, known to Ancient Greeks as Strongýlē, an Italian island in the Tyrrhenian Sea
• Strongyli Megistis, a Greek islet in the eastern Mediterranean Sea