Suproclone

Summary

Suproclone is a sedative and anxiolytic drug in the cyclopyrrolone family of drugs, developed by the French pharmaceutical company Rhône-Poulenc.[1] Other cyclopyrrolone drugs include zopiclone, pagoclone and suriclone.

Suproclone
Clinical data
ATC code
  • none
Identifiers
  • [6-(7-chloro-1,8-naphthyridin-2-yl)-5-oxo-3,7-dihydro-2H-[1,4]dithiino[2,3-c]pyrrol-7-yl] 4-propanoylpiperazine-1-carboxylate
CAS Number
  • 76535-71-2 checkY
PubChem CID
  • 53696
ChemSpider
  • 48481 checkY
UNII
  • J4AM5D708G
KEGG
  • D05975 checkY
ChEMBL
  • ChEMBL2105531
ECHA InfoCard100.071.330 Edit this at Wikidata
Chemical and physical data
FormulaC22H22ClN5O4S2
Molar mass520.02 g·mol−1
3D model (JSmol)
  • Interactive image
  • O=C(N5CCN(C(=O)OC4C=1SCCSC=1C(=O)N4c2nc3nc(Cl)ccc3cc2)CC5)CC
  • InChI=1S/C22H22ClN5O4S2/c1-2-16(29)26-7-9-27(10-8-26)22(31)32-21-18-17(33-11-12-34-18)20(30)28(21)15-6-4-13-3-5-14(23)24-19(13)25-15/h3-6,21H,2,7-12H2,1H3 checkY
  • Key:IBAUKGNDWVSETP-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Suproclone is very similar in structure to the related drug suriclone, but little information has been published about it specifically. However it can be expected that the mechanism of action by which suproclone produces its sedative and anxiolytic effects is by modulating benzodiazepine receptors (resulting in an increased response to endogenous GABA), in a similar manner to other drugs of this class.[2][3]

References edit

  1. ^ Psychotropics.dk. "suproclone". Retrieved 24 August 2009.
  2. ^ Gardner CR (1988). "Pharmacological profiles in vivo of benzodiazepine receptor ligands". Drug Development Research. 12 (1): 1–28. doi:10.1002/ddr.430120102. S2CID 85573551.
  3. ^ Doble A, Martin I, Nutt D (23 October 2003). Calming the brain: benzodiazepines and related drugs from laboratory to clinic. Informa Healthcare. ISBN 1-84184-052-1.