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TRNA (cytidine56-2'-O)-methyltransferase 
Summary
tRNA (cytidine56-2'-O)-methyltransferase (EC 2.1.1.206, aTrm56, tRNA ribose 2'-O-methyltransferase aTrm56, PAB1040 (gene)) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (cytidine56-2'-O)-methyltransferase.[1][2] This enzyme catalyses the following chemical reaction
| tRNA (cytidine56-2'-O)-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.206 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- S-adenosyl-L-methionine + cytidine56 in tRNA S-adenosyl-L-homocysteine + 2'-O-methylcytidine56 in tRNA
The archaeal enzyme specifically catalyses the S-adenosyl-L-methionine dependent 2'-O-ribose methylation of cytidine at position 56 in tRNA transcripts.
References edit
- ^ Renalier MH, Joseph N, Gaspin C, Thebault P, Mougin A (July 2005). "The Cm56 tRNA modification in archaea is catalyzed either by a specific 2'-O-methylase, or a C/D sRNP". RNA. 11 (7): 1051–63. doi:10.1261/rna.2110805. PMC 1370790. PMID 15987815.
- ^ Kuratani M, Bessho Y, Nishimoto M, Grosjean H, Yokoyama S (January 2008). "Crystal structure and mutational study of a unique SpoU family archaeal methylase that forms 2'-O-methylcytidine at position 56 of tRNA". Journal of Molecular Biology. 375 (4): 1064–75. doi:10.1016/j.jmb.2007.11.023. PMID 18068186.
External links edit
- TRNA+(cytidine56-2'-O)-methyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
