Tacalcitol (1,24-dihydroxyvitamin D3) is a synthetic vitamin D3 analog.[1] Tacalcitol is marketed under several names, including Curatoderm and Bonalfa.
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Other names | (1α,24R)-1,24-Dihydroxyvitamin D3 |
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Routes of administration | Topical |
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ECHA InfoCard | 100.220.855 |
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Formula | C27H44O3 |
Molar mass | 416.646 g·mol−1 |
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It is on the World Health Organization's List of Essential Medicines.[2]
Tacalcitol reduces excessive cell turnover in the epidermis by interacting with vitamin D receptors on keratinocytes.[3][4]
It is usually prescribed by a general practitioner or dermatologist for the treatment of psoriasis, chronic chapped lips and other severe dry skin conditions because of its ability to reduce excessive skin cell turnover.[1] It is available as an ointment or lotion.
It has also been used for vitiligo[5][6] and Hailey-Hailey disease.[7]