The Takeda Pharmaceutical Company Limited (武田薬品工業株式会社, Takeda Yakuhin Kōgyō kabushiki gaisha) [takeꜜda jakɯçiŋ koꜜːɡʲoː] is a Japanese multinational pharmaceutical company, with partial American and British roots. It is the largest pharmaceutical company in Asia and one of the top 20 largest pharmaceutical companies in the world by revenue (top 10 following merger with Shire). The company has over 49,578 employees worldwide and achieved US $19.299 billion in revenue during the 2018 fiscal year. The company is focused on metabolic disorders, gastroenterology, neurology, inflammation, as well as oncology through its independent subsidiary, Takeda Oncology. Its headquarters is located in Chuo-ku, Osaka, and it has an office in Nihonbashi, Chuo, Tokyo. In January 2012, Fortune Magazine ranked the Takeda Oncology Company as one of the 100 best companies to work for in the United States. As of 2015, Christophe Weber was appointed as the CEO and President of Takeda.
|Takeda Yakuhin Kōgyō kabushiki gaisha|
|Formerly||Chobei Takeda & Co., Ltd. (1925-1943)|
Takeda Pharmaceutical Industries, Ltd. (English name only 1943-1961)
Takeda Chemical Industries, Ltd. (English name only 1961-2004)
|Founded||Doshomachi, Osaka, Japan (June 12, 1781)|
|Founder||Chobei Takeda I|
(Chairman of the Board)
(President & CEO)
|Revenue||¥1,770,531 million (FY 2018)[* 1]|
|¥241,789 million (FY 2018)[* 1]|
|¥186,886 million (FY 2012)[* 1]|
|Total assets||¥4,106,463 billion (FY 2018)[* 1]|
|Total equity||¥1,997,424 billion (FY 2018)[* 1]|
|Owner||Nippon Life (2.24%),State Street Corporation(1.50%)|
Number of employees
(18,378) in United States (5,350) in Japan
|Website||takeda.com (Global website)|
|Footnotes / references|
Takeda Pharmaceuticals was founded in 1781, and was incorporated on January 29, 1925.
In February 2008, Takeda acquired the Japanese operations of Amgen and rights to a dozen of the California biotechnology company's pipeline candidates for the Japanese market. In April, Takeda acquired Millennium Pharmaceuticals of Cambridge, Massachusetts, a company specializing in cancer drug research, for US$8.8 billion. The acquisition brought in Velcade, a drug indicated for hematological malignancies, as well as a portfolio of pipeline candidates in the oncology, inflammation, and cardiovascular therapeutic areas. Millennium now operates as an independent subsidiary. In May, the company licensed non-exclusively the RNAi technology platform developed by Alnylam Pharmaceuticals, creating a potentially long-term partnership between the companies.
In May 2012, Takeda purchased Brazilian pharmaceutical company Multilab for R$540 million. In June, Takeda announced it would acquire URL Pharma, then run by the founder's son Richard Roberts, for US$800 million.
In September 2014, Takeda announced it would team up with BioMotiv to identify and develop new compounds over a five-year period, worth approximately US$25 million. On 30 September 2014, Takeda announced it would expand a collaboration with MacroGenics, valued up to US$1.6 billion. The collaboration focused on the co-development of the preclinical autoimmune compound MGD010. MGD010 is a therapy which targets the B-cell surface proteins CD32B and CD79B, and is indicated for lupus and rheumatoid arthritis.
In 2015, Takeda sold its respiratory drugs business to AstraZeneca for $575 million (about £383 million), which included roflumilast and ciclesonide. On November, the U.S. Food and Drug Administration approved Ixazomib developed by Takeda for use in combination with lenalidomide and dexamethasone for the treatment of multiple myeloma after at least one prior therapy.
In December 2016, the company spun out its neuroscience research division into Cerevance, a joint venture along with Lightstone Ventures.
In January 2019, Takeda acquired Shire for more than US$50 billion. In October, Takeda announced it had sold a portfolio of over-the-counter and prescription medicines in the Middle East and Africa to Swiss pharmaceuticals company Acino International for more than $200 million.
In January 2020, Takeda announced a research partnership with the Massachusetts Institute of Technology (MIT) to advance discoveries in artificial intelligence and health. The MIT-Takeda Program is housed in the MIT Jameel Clinic, and is led by Professor James J. Collins, with a steering committee led by Professor Anantha P. Chandrakasan, dean of the MIT School of Engineering, and Anne Heatherington, senior vice president and head of Data Sciences Institute (DSI) at Takeda. In March 2020, Takeda announced that it has entered into an exclusive agreement to divest a portfolio of non-core products in Latin America to Hypera S.A. for a total value of $825 million.
In March 2021, the company announced it would acquire Maverick Therapeutics, Inc. and its two major programs TAK-186 (MVC-101) in trials for the treatment of EGFR-expressing tumours and TAK-280 (MVC-280) for use in the treatment of patients with B7H3-expressing tumors. In October, they acquired GammaDelta Therapeutics and its gamma delta (γδ) T cell immunotherapy programme.
In January 2022, Takeda announced it would exercise its option to acquire Adaptate Biotherapeutics and its antibody-based γδ T cell technology, reuniting Adaptate and its former parent company, GammaDelta Therapeutics, in a single organisation.
In 1977, Takeda first entered the U.S. pharmaceutical market by developing a joint venture with Abbott Laboratories called TAP Pharmaceuticals. Through TAP Pharmaceuticals Takeda and Abbott launched blockbuster drugs Lupron (leuprorelin), in 1985, then Prevacid (lansoprazole), in 1995.
In 2001, TAP's illegal marketing of Lupron resulted in both civil and criminal charges by the U.S. Department of Justice and the Illinois attorney general for federal and state medicare fraud. TAP was fined $875 million, then reported as the largest pharmaceutical settlement in history.
In March 2008, Takeda and Abbott Laboratories announced plans to conclude their 30-year-old joint venture, TAP Pharmaceuticals. The split resulted in Abbott acquiring U.S. rights to Lupron and the drug's support staff. Takeda received rights to Prevacid and TAP's pipeline candidates. The move also increased Takeda's headcount by 3,000 employees.
In November 2019, Takeda entered an agreement to sell its over-the-counter and prescription drugs businesses in Russia, Georgia, Armenia, Azerbaijan, Belarus, Kazakhstan, and Uzbekistan to Stada Arzneimittel for $660 million.
In June 2020, Takeda announced that it was divesting 18 over-the-counter and prescription drugs marketed in the Asia-Pacific region to South Korea's Celltrion in a deal worth $278 million.
Takeda operates two primary bases in Japan in Osaka and Tokyo. Its United States subsidiary is based in Cambridge, Massachusetts, and all Global Operations outside Japan and the U.S. are based in Opfikon (Zurich), Switzerland. The company maintains research and development sites in Japan, the United States, the United Kingdom and Singapore, with manufacturing facilities across the globe.
In April 2015 Takeda agreed to pay a settlement of $2.37 billion to an estimated 9,000 people who submitted claims alleging that pioglitazone was responsible for giving them bladder cancer. The company said the decision is expected to resolve the “vast majority” of these cases. Takeda will put the money into a settlement fund if 95 percent of plaintiffs agree to the accord, according to which each claimant would get an average $267,000. However, the exact amount for each plaintiff will be evaluated based on cumulative dosage, extent of injuries and past history of smoking. In 2014, a plaintiff was awarded $9 billion in punitive damages after a federal court found Takeda hid the cancer risks of their diabetes medicine, but the amount was later reduced to $26 million by a judge who deemed the charge excessive.
And it didn't include earlier-announced deals completed in 2019, such as Takeda Pharmaceutical's £46 billion ($58.6 billion) purchase of Shire.