Tando Muhammad Khan was founded by Mir Muhammad Khan Talpur Shahwani, who died in 1813.

During the British period, it was a seat of assistant collector. Its status was changed to Municipality in 1856. Tando Muhammad Khan was carved out of Hyderabad district in April 2005 by then adviser chief minister of Sindh, Mir Ali Nawaz Khan Talpur. Syed, Bukharis, Mirs and Nizamanis are prominent families in Tando Mohammad Khan, highly active in the politics of Tando Mohammad Khan for centuries.

There are four big sugar mills in Tando Mohammad khan city, and around dozen of rice mills which provide employment to the local people on seasonal bases. The mills are located outskirts of the city. Banking and service remain backbone of the city's economic life. Traditional shawls called "Ajrak" is among the most famous Sindhi culture wearing is also produced in Tando Muhammad Khan.

The town is located at 25°8′N and 68°32′E at an elevation of 11 metres^[3] on the right bank of Fuleli canal (old name of Fuleli was Gooni) at distance of 21 miles from Hyderabad. There are 8 police stations in District T.M. Khan which are PS Tando Muhammad Khan, PS Bulri Shah Karim, PS Abadgar, PS Taluka, PS Sheikh Burkio, PS Moya, PS Tando Ghulam Haider and PS Mullakatiar. Taluka Tando Ghulam Hyder consists of Four Union Council

• Tando Ghulam Hyder (main)
• Nazarpur
• Ghulam Shah Bagrani
• Dandies

Union Council Nazarpur consists of Markaz which are given below.

• Jagsyani. jagsi Muslim Community political background and this Community belongs to agriculture as (Landlord) the jagsi Community consists on village
• Wahid Dino Jagsi
• Haji Karmillah Jagsi
• Abdul Rehman Jagsi
• Ghulam Mustafa Jagsi
• Mohammad Haroon Jagsi

People of various background coexist here peacefully. Majority of population consists of Sindhi people, Urdu speaking (mohajir) are the largest minority in Tando Mohammad Khan city. Others ethnic groups are Bagri, Bheels, Kolli, Meghwars, ranghar or rangar, mehwati, Punjabi, Pathans, and few others. All villages are surrounding in the area of Tando Ghulam Hyder union council Nazarpur markaz Jagsyani whole Jagsi Muslim Sunni Community are well-educated communities that are 500 years older living at District Tando Muhammad Khan Taluka Tando Ghulam Hyder.

The taluka headquarters Tando Ghulam Hyder was created in 2005 by Arbab Ghulam Rahim Chief Minister Sindh.

There are different communities are living in taluka H/Q Tando Ghulam Hyder for instance: Bhatti Community, Waryah Community, Peer, Sheedi, Khaskheli, Kunbhar and Kathbabhan. Whereas Bhatti community is a well-educated family in Tando Ghulam Hyder and Waryah community is related with agriculture and trade.

Sindhi and Urdu are the primary language of TMK city. Both are understood and spoken universally. TMK city is linguistically quite rich as it hosts many ethnic and linguistics groups. So, following are the languages spoken in TMK city: Bheeli, Gujarati, Kutchi, Memoni, Mehwati, Bagri, Punjabi, Pushto, Pothowari, Seraiki and Brohui.

• Rajo Nizamani

• Shahwani Talpurs of Tando Muhammad Khan
• The Royal Talpurs of Sindh
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