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Terodiline

Summary

Terodiline is a drug used in urology as an antispasmodic.

Terodiline
Clinical data
ATC code
Identifiers
  • N-tert-butyl-4,4-di(phenyl)butan-2-amine
CAS Number
  • 15793-40-5 checkY
    7082-21-5 (hydrochloride)
PubChem CID
  • 23480
ChemSpider
  • 21952 checkY
UNII
  • 70KG06964W
ChEMBL
  • ChEMBL363295 checkY
CompTox Dashboard (EPA)
  • DTXSID60860001 Edit this at Wikidata
Chemical and physical data
FormulaC20H27N
Molar mass281.443 g·mol−1
3D model (JSmol)
  • Interactive image
  • c1ccccc1C(c2ccccc2)CC(NC(C)(C)C)C
  • InChI=1S/C20H27N/c1-16(21-20(2,3)4)15-19(17-11-7-5-8-12-17)18-13-9-6-10-14-18/h5-14,16,19,21H,15H2,1-4H3 checkY
  • Key:UISARWKNNNHPGI-UHFFFAOYSA-N checkY
  (verify)

It relaxes the smooth muscle and used to reduce bladder tone in treatment of urinary frequency and incontinence. Muscle relaxation caused by terodiline, is probably due to its anticholinergic and calcium antagonist activity.

However, it also blocks IKr (Kv11.1) channels (see hERG gene) so can pose a risk for torsades de pointes. This cardiotoxicity is concentration dependent.[1]

References edit

  1. ^ Thomas SH, Higham PD, Hartigan-Go K, Kamali F, Wood P, Campbell RW, Ford GA (1995). "Concentration dependent cardiotoxicity of terodiline in patients treated for urinary incontinence". Br Heart J. 74 (1): 53–6. doi:10.1136/hrt.74.1.53. PMC 483946. PMID 7662454.