The Best American Science and Nature Writing is a yearly anthology of popular science magazine articles published in the United States. It was started in 2000 and is part of The Best American Series published by Houghton Mifflin. Articles are chosen using the same procedure with other titles in the Best American series; the series editor chooses about 100 article candidates, from which the guest editor picks 25 or so for publication; the remaining runner-up articles listed in the appendix. The series is available through Mariner Books, which since 2019 is an imprint of HarperCollins.

Burkhard Bilger was the series editor for 2000 and 2001. Tim Folger was the series editor from 2002 to 2018. Jaime Green has been the series editor since 2019.