Thromboxane B2

Summary

Thromboxane B2 (TXB2) is an inactive metabolite/product of thromboxane A2. It is almost completely cleared in the urine.

Thromboxane B2
Names
Preferred IUPAC name
(5Z)-7-{(2R,3S,4S,6Ξ)-4,6-Dihydroxy-2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]oxan-2-yl}hept-5-enoic acid
Identifiers
  • 54397-85-2 checkY
3D model (JSmol)
  • Interactive image
ChEBI
  • CHEBI:28728 ☒N
ECHA InfoCard 100.165.003 Edit this at Wikidata
MeSH Thromboxane+B2
  • 5283137
UNII
  • V94M3R26ZV checkY
  • DTXSID60903947 Edit this at Wikidata
  • CCCCC[C@H](O)\C=C\[C@H]1OC(O)C[C@H](O)[C@@H]1C\C=C/CCCC(O)=O
Properties
C20H34O6
Molar mass 370.48 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

It itself is not involved in platelet activation and aggregation in case of a wound, but its precursor, thromboxane A2, is. Thromboxane A2 synthesis is the target of the drug aspirin, which inhibits the COX-1 enzyme (the source of thromboxane A2 in platelets). [1]

2-(3,4-Di-hydroxyphenyl)-ethanol (DHPE) is a phenolic component of extra-virgin olive oil. An olive oil fraction containing DHPE can inhibit platelet aggregation and thromboxane B2 formation in vitro.[2]

References edit

  1. ^ "Definition: thromboxane b2 from Online Medical Dictionary". Retrieved 2008-11-02.
  2. ^ Inhibition of platelet aggregation and eicosanoid production by phenolic components of olive oil. Anna Petroni, Milena Blasevich, Marco Salami, Nadia Papini, Gian F. Montedoro and Claudio Gallia, Thrombosis Research, 15 April 1995, Volume 78, Issue 2, Pages 151–160, doi:10.1016/0049-3848(95)00043-7