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Timepidium bromide

Summary

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Timepidium bromide (INN) is an anticholinergic. It is used in the symptomatic treatment of visceral spasms.[1] It is also used to relieve pain associated with various gastrointestinal disorders.[2] The quaternary nitrogen prevents it from crossing the blood brain barrier, so it is peripherally acting with no central side effects.

Timepidium bromide
Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
administration		SC, IM, IV
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
  • 3-(di-2-thienylmethylene)-5-methoxy-1,1-dimethylpiperidinium bromide
CAS Number
  • 35035-05-3 checkY
PubChem CID
  • 160243
ChemSpider
  • 140841 ☒N
UNII
  • 8R9E4766V4
CompTox Dashboard (EPA)
  • DTXSID4023672 Edit this at Wikidata
Chemical and physical data
FormulaC17H22BrNOS2
Molar mass400.39 g·mol−1
3D model (JSmol)
  • Interactive image
  • C[N+]1(CC(CC(=C(C2=CC=CS2)C3=CC=CS3)C1)OC)C.[Br-]
  • InChI=1S/C17H22NOS2.BrH/c1-18(2)11-13(10-14(12-18)19-3)17(15-6-4-8-20-15)16-7-5-9-21-16;/h4-9,14H,10-12H2,1-3H3;1H/q+1;/p-1 ☒N
  • Key:QTSXMEPZSHLZFF-UHFFFAOYSA-M ☒N
 ☒NcheckY (what is this?)  (verify)

The same compound sans the quaternary methyl group and the methoxy ether is called tipepidine.[3]

References edit

  1. ^ "Timepidium bromide: Indication, Dosage, Side Effect, Precaution | MIMS Malaysia". www.mims.com. Retrieved 2021-07-05.
  2. ^ "Timepidium Bromide Tablets 30mg SAWAI 100 Tablets｜Natural Pharmacy". www.mimaki-family-japan.com. Retrieved 2021-07-05.
  3. ^ Shah R, Verma PK (December 2018). "Therapeutic importance of synthetic thiophene". Chemistry Central Journal. 12 (1): 137. doi:10.1186/s13065-018-0511-5. PMC 6768136. PMID 30564984.