Tlepolemus was regent of Egypt in the Ptolemaic period under the reign of the boy-king Ptolemy V. He was briefly prominent at the end of the 3rd century BC; his dates of birth and death are not known.

Tlepolemus was a member of a distinguished Persian family who had migrated to Egypt in the late 3rd century BC.^[1] He was strategos (military governor) of the region of Pelusium in 202 BC when the regent Agathocles and his family were overthrown and killed in a popular uprising. Tlepolemus took Agathocles' place as regent, but held it only until the following year, 201 BC, when he was in his turn replaced by Aristomenes of Alyzia.