Triprolidine is an over-the-counter antihistamine with anticholinergic properties.[1] It is used to combat the symptoms associated with allergies and is sometimes combined with other cold medications designed to provide general relief for flu-like symptoms.[2] As with many antihistamines, the most common side effect is drowsiness.[1]
Clinical data | |
---|---|
Trade names | Flonase Nighttime Allergy Relief, Actidil, Myidil, Actifed (in the latter combined with pseudoephedrine and either dextromethorphan or guaifenesin) |
AHFS/Drugs.com | Monograph |
Pregnancy category |
|
Routes of administration | Oral |
ATC code |
|
Legal status | |
Legal status |
|
Pharmacokinetic data | |
Bioavailability | 4% oral |
Protein binding | 90% |
Metabolism | Hepatic (CYP2D6) |
Elimination half-life | 4–6 hours |
Excretion | Renal |
Identifiers | |
| |
CAS Number |
|
PubChem CID |
|
IUPHAR/BPS |
|
DrugBank |
|
ChemSpider |
|
UNII |
|
KEGG |
|
ChEBI |
|
ChEMBL |
|
CompTox Dashboard (EPA) |
|
ECHA InfoCard | 100.006.934 |
Chemical and physical data | |
Formula | C19H22N2 |
Molar mass | 278.399 g·mol−1 |
3D model (JSmol) |
|
Melting point | 60 °C (140 °F) |
Solubility in water | 500 mg/mL (20 °C) |
| |
| |
(what is this?) (verify) |
It was patented in 1948 and came into medical use in 1953.[3]