Tuaminoheptane (INN , BAN ; brand names Heptin, Heptadrine, Tuamine; also known as tuamine and 2-aminoheptane) is a sympathomimetic agent and vasoconstrictor which was formerly used as a nasal decongestant.[2][3][4] It has also been used as a stimulant.[5][6]
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Trade names | Heptin, Heptadrine, Tuamine |
Other names | Tuamine; 2-Aminoheptane; 2-Heptanamine; 1-Methylhexylamine |
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ECHA InfoCard | 100.004.233 |
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Formula | C7H17N |
Molar mass | 115.220 g·mol−1 |
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Density | 0.766 g/mL g/cm3 |
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Tuaminoheptane has been found to act as a reuptake inhibitor and releasing agent of norepinephrine, which may underlie its decongestant and stimulant effects.[7][8][6] It is an alkylamine.[6] The chemical structure of the drug differs from that of other norepinephrine releasing agents, such as the phenethylamines, which, in contrast to tuaminoheptane, have an aromatic ring in their structure.[8] Tuaminoheptane is also a skin irritant and can cause contact dermatitis via inhibition of volume-regulated anion channels, which limits its usefulness as a decongestant.[9]
Tuaminoheptane is on the 2011 list of prohibited substances published by the World Anti-Doping Agency.[5]